Grosche J, Matyash V, Möller T, Verkhratsky A, Reichenbach A, Kettenmann H
Paul Flechsig Institute for Brain Research, University of Leipzig, Germany.
Nat Neurosci. 1999 Feb;2(2):139-43. doi: 10.1038/5692.
Astrocytes are considered a reticulate network of cells, through which calcium signals can spread easily. In Bergmann glia, astrocytic cells of the cerebellum, we identified subcellular compartments termed 'glial microdomains'. These elements have a complex surface consisting of thin membrane sheets, contain few mitochondria and wrap around synapses. To test for neuronal interaction with these structures, we electrically stimulated parallel fibers. This stimulation increased intracellular calcium concentration ([Ca2+]i) in small compartments within Bergmann glial cell processes similar in size to glial microdomains. Thus, a Bergmann glial cell may consist of hundreds of independent compartments capable of autonomous interactions with the particular group of synapses that they ensheath.
星形胶质细胞被认为是一个细胞网状网络，钙信号可通过该网络轻松传播。在伯格曼胶质细胞（小脑的星形胶质细胞）中，我们识别出了被称为“胶质微区”的亚细胞区室。这些结构具有由薄细胞膜片组成的复杂表面，含有少量线粒体，并包裹着突触。为了测试神经元与这些结构的相互作用，我们对平行纤维进行了电刺激。这种刺激增加了伯格曼胶质细胞突起内与胶质微区大小相似的小区域内的细胞内钙浓度（[Ca2+]i）。因此，一个伯格曼胶质细胞可能由数百个能够与它们所包裹的特定突触群进行自主相互作用的独立区室组成。
