Ala T A, Yang K H, Sung J H, Frey W H
Alzheimer's Treatment and Research Center, Department of Neurology, Ramsey Clinic/HealthPartners, University of Minnesota, St. Paul, USA.
J Neural Transm (Vienna). 1999;106(1):47-57. doi: 10.1007/s007020050140.
In a retrospective clinicopathological study, we examined the substantia nigra (SN) of 48 dementia patients with SN Lewy bodies (LBs) to determine if the severity of degeneration correlated with either the occurrence of signs of parkinsonism at dementia presentation or with the frequency of treatment for parkinsonism during the disease course. The SN specimens were graded for microscopic degeneration using a semi-quantitative five-tiered scale. Whereas no correlation was found between the grade of degeneration and occurrence of signs at presentation (r = -0.16, p = 0.18), with 16 of 38 patients having had signs reported, a more severe grade was statistically correlated with an increased frequency of treatment during the course (r = 0.41, p = 0.004), with ten of 41 patients having been treated for parkinsonism. Contrary to our expectations, we found that fewer than half of the patients with the two most severe grades of degeneration presented with signs of parkinsonism or were ever treated for parkinsonism.
在一项回顾性临床病理研究中，我们检查了48例患有黑质路易小体（LB）的痴呆患者的黑质（SN），以确定变性的严重程度是否与痴呆表现时帕金森综合征体征的出现或疾病过程中帕金森综合征的治疗频率相关。使用半定量五级量表对SN标本的微观变性进行分级。虽然在变性程度与表现时体征的出现之间未发现相关性（r = -0.16，p = 0.18），38例患者中有16例报告有体征，但更严重的分级与病程中治疗频率的增加在统计学上相关（r = 0.41，p = 0.004），41例患者中有10例接受了帕金森综合征治疗。与我们的预期相反，我们发现，在变性程度最严重的两级患者中，不到一半的患者出现帕金森综合征体征或曾接受过帕金森综合征治疗。
