Dierks T, Kuhn W, Oberle S, Müller T, Maurer K
Dept. of Psychiatry I, University of Frankfurt/Main, Frankfurt.
Eur Arch Psychiatry Clin Neurosci. 1999;249(1):15-20. doi: 10.1007/s004060050060.
Electroencephalographic (EEG) generators were investigated in 13 patients suffering from hepatolenticular degeneration with and without neurological symptoms and in 13 healthy subjects for comparison by the use of FFT approximation. Quantitative assessment of motor deficits and psychiatric disturbances was correlated with EEG features. We found mainly an increase in delta activity, a decrease in alpha activity combined with a more posterior localisation of the EEG generators in the delta band and a more anterior one in the alpha band in patients compared with healthy controls. The localisation of the EEG generators in the patients with clinical apparent neurological symptoms were in all frequency bands more superficial compared with controls and patients without neurological symptoms. With longer duration of the disease, the lower the premorbid intelligence the more posterior was the delta EEG generator localised. Although the alpha EEG generator was more anteriorly localised with longer duration of the disease and more severe cognitive deficits, it was more superficial with more pronounced psychiatric symptoms, more severe cognitive deficits, lower premorbid intelligence and more pronounced motor disabilities. With more pronounced psychiatric symptoms and cognitive deficits, the beta EEG generator was more anteriorly localised. The present study demonstrated that a significant deviant EEG pattern exists between patients with and without clinical neurological symptoms and that stage-dependent alterations in psychiatric symptoms and cognitive ability are reflected on the EEG.
通过快速傅里叶变换（FFT）近似法，对13例有或无神经症状的肝豆状核变性患者及13名健康受试者的脑电图（EEG）发生器进行了研究。对运动功能障碍和精神障碍进行定量评估，并将其与脑电图特征相关联。与健康对照组相比，我们发现患者主要表现为δ波活动增加，α波活动减少，且EEG发生器在δ频段的定位更靠后，在α频段的定位更靠前。有明显神经症状的患者，其EEG发生器在所有频段的定位都比对照组及无神经症状的患者更表浅。病程越长，病前智力越低，δ波EEG发生器的定位越靠后。虽然随着病程延长和认知缺陷加重，α波EEG发生器的定位更靠前，但在精神症状更明显、认知缺陷更严重、病前智力更低及运动障碍更明显时，其定位更表浅。精神症状和认知缺陷越明显，β波EEG发生器的定位越靠前。本研究表明，有或无临床神经症状的患者之间存在显著异常的脑电图模式，且精神症状和认知能力的分期依赖性改变在脑电图上有所体现。
