Chu N S, Chu C C, Tu S C, Huang C C
Department of Neurology, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan.
J Neurol Sci. 1991 Nov;106(1):1-9. doi: 10.1016/0022-510x(91)90186-b.
Computerized EEG spectral analysis and topographic mapping were performed on 14 patients with Wilson's disease (WD) and 10 normal subjects of comparable ages. The predominant EEG changes in WD were diffuse but uneven topographic abnormalities with a decrease in alpha activity, an increase in theta and delta activities, and a low voltage background mainly in the alpha frequency band. Eleven patients (80%) had at least one of the above EEG changes. Furthermore, topographic mapping provided more clearly defined foci of slowing and epileptiform activity. Patients with cerebral white matter involvement, akinetic-rigid syndrome, dystonia, or psychiatric symptoms tended to have more abnormal EEGs. It is concluded that EEG changes in WD are common and the quantitative EEG analysis can increase the likelihood of detecting mild or even subtle EEG abnormalities in individual patients as well as in the patient group.
对14例威尔逊病（WD）患者和10名年龄相仿的正常受试者进行了计算机化脑电图频谱分析和地形图绘制。WD患者脑电图的主要变化为弥漫性但不均匀的地形图异常，α活动减少，θ和δ活动增加，且主要在α频段出现低电压背景。11例患者（80%）至少有上述脑电图变化之一。此外，地形图绘制能更清晰地显示慢波和癫痫样活动的病灶。有脑白质受累、运动不能-强直综合征、肌张力障碍或精神症状的患者脑电图往往更异常。结论是，WD患者脑电图变化常见，定量脑电图分析可提高在个体患者以及患者群体中检测轻度甚至细微脑电图异常的可能性。
