Fugelseth D, Lindemann R, Liestøl K, Kiserud T, Langslet A
Department of Paediatrics, Ullevål University Hospital, Oslo, Norway.
Early Hum Dev. 1998 Dec;53(2):163-9. doi: 10.1016/s0378-3782(98)00051-6.
To assess ultrasonographically the flow pattern and the time of postnatal closure of ductus venosus in preterm infants < or = 32 weeks.
Thirty-three preterm infants < or = 32 weeks were studied within the first 1 to 5 days of life and followed every second day with ultrasound until no flow was detected either through the ductus venosus or the ductus arteriosus.
The ductus venosus was closed in only 9% by day 3, in 40% by day 8 and 88% by day 18. All were closed by day 37. This is significantly later than in healthy term neonates. Closure of the ductus venosus was not significantly correlated with closure of ductus arteriosus.
The ductus venosus shows a delayed closure in preterm infants, with no significant correlation to the closure of the ductus arteriosus or the condition of the infant. We speculate that immaturity of the ductus venosus and possibly increased levels of dilating prostaglandins leads to a delayed obliteration of the vessel. An open ductus venosus represents a portocaval shunt and may have metabolical and pharmacological consequences.
通过超声评估孕周小于或等于32周的早产儿静脉导管的血流模式及出生后闭合时间。
对33例孕周小于或等于32周的早产儿在出生后1至5天内进行研究，并每隔一天用超声进行随访，直至静脉导管或动脉导管均未检测到血流。
出生后第3天仅有9%的静脉导管闭合，第8天为40%，第18天为88%。所有静脉导管均在第37天闭合。这明显晚于健康足月儿。静脉导管的闭合与动脉导管的闭合无显著相关性。
早产儿静脉导管闭合延迟，与动脉导管闭合或婴儿状况无显著相关性。我们推测静脉导管不成熟以及可能升高的扩张性前列腺素水平导致血管闭塞延迟。开放的静脉导管代表门静脉-腔静脉分流，可能产生代谢和药理学后果。
