阿尔茨海默型痴呆患者海马中环状AMP反应元件结合蛋白磷酸化受损。
Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type.
作者信息
Yamamoto-Sasaki M, Ozawa H, Saito T, Rösler M, Riederer P
机构信息
Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany.
出版信息
Brain Res. 1999 Apr 10;824(2):300-3. doi: 10.1016/s0006-8993(99)01220-2.
Cyclic AMP (cAMP) is disrupted in the brain in dementia of the Alzheimer type (DAT). We investigated whether the cAMP reduction is accompanied by an alteration in the cAMP response element binding protein (CREB) downstream in DAT and control hippocampi. Immunoreactivity of pCREB was significantly decreased in DAT, while total CREB level was unchanged. These findings indicate that impaired cAMP signaling may contribute to the pathophysiology of the disease.
环磷酸腺苷（cAMP）在阿尔茨海默型痴呆（DAT）患者的大脑中受到破坏。我们研究了在DAT和对照海马体中，cAMP减少是否伴随着其下游的环磷酸腺苷反应元件结合蛋白（CREB）的改变。DAT患者中磷酸化CREB（pCREB）的免疫反应性显著降低，而总CREB水平未变。这些发现表明，cAMP信号受损可能导致该疾病的病理生理过程。
Zotero 插件