West W O
South Med J. 1976 Nov;69(11):1516-7. doi: 10.1097/00007611-197611000-00036.
A 74-year-old white man with established polycythemia vera was treated with radioactive phosphorus after phlebotomies alone failed to control his disease. About 2 3/4 years later he died of multiple myeloma. The mutagenic effect of radioactive phosphorus may have caused or possibly accelerated preexisting myeloma. Basic nonmalignant disease deserves careful consideration before radiation or radiomimetic agents are used. One might consider a probably less mutagenic drug such as hydroxyurea in patients with polycythemia vera when phlebotomy alone does not give good control of red cell mass and thrombocytosis.
一名74岁患有真性红细胞增多症的白人男性，在仅通过放血疗法无法控制病情后，接受了放射性磷治疗。大约2又3/4年后，他死于多发性骨髓瘤。放射性磷的诱变作用可能导致了已存在的骨髓瘤，或者可能加速了其发展。在使用辐射或类辐射剂之前，对基础非恶性疾病应予以仔细考虑。当仅靠放血疗法不能很好地控制红细胞量和血小板增多时，对于真性红细胞增多症患者，可考虑使用可能诱变作用较小的药物，如羟基脲。
