Prósper F, Paloma M J, Rifón J, Cuesta B, Hermida J, Rocha E
Servicio de Hematología, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona.
Sangre (Barc). 1993 Dec;38(6):497-9.
We present a patient diagnosed of polycythemia vera who developed a multiple myeloma 13 years after the initial diagnosis of polycythemia vera. Although an unusual finding, another 17 patients with polycythemia and myeloma have been described. In some patients the diagnosis of both diseases was simultaneous but in most cases myeloma developed years after polycythemia vera. Some patients received only venipuncture for treatment of polycythemia vera so the appearance of multiple myeloma could not be explained on the grounds of chemotherapy induced second neoplasm. An explanation for this association is suggested.
我们报告一名被诊断为真性红细胞增多症的患者，在真性红细胞增多症初次诊断13年后发生了多发性骨髓瘤。尽管这是一个不寻常的发现，但另外已有17例真性红细胞增多症合并骨髓瘤的患者被描述。在一些患者中，两种疾病的诊断是同时做出的，但在大多数情况下，骨髓瘤在真性红细胞增多症之后数年才发生。一些患者仅接受静脉放血治疗真性红细胞增多症，因此多发性骨髓瘤的出现不能用化疗诱发第二肿瘤来解释。本文提出了对这种关联的一种解释。
