Taylor C L, Freeman J H, Holt W, Gabriel M
Department of Psychology and the Beckman Institute, University of Illinois at Urbana-Champaign, Urbana 61801, USA.
Behav Neurosci. 1999 Feb;113(1):62-77. doi: 10.1037//0735-7044.113.1.62.
Neuronal activity was recorded in the cingulate cortex and the limbic thalamus in Dutch-belted rabbits (Oryctolagus cuniculus) exposed to cocaine (8 mg/kg/day i.v.) or saline in utero during acquisition and reversal learning of a discriminative avoidance response. Anterior cingulate cortical excitatory training-induced activity (TIA) was attenuated in cocaine-exposed female rabbits during acquisition and reversal learning, but only during reversal learning in male rabbits. Posterior cingulate cortical excitatory TIA was lessened in cocaine-exposed rabbits during acquisition, whereas discrimination between the positive and negative cues was enhanced. Neuronal firing was attenuated in the anterior ventral thalamus in cocaine-exposed rabbits during acquisition and reversal learning. Behavioral learning was normal in cocaine-exposed rabbits. Other data suggest that rabbits exposed to cocaine in utero exhibit a learning deficit when trained with nonsalient cues.
在荷兰带兔（穴兔）的扣带回皮质和边缘丘脑记录神经元活动，这些兔子在辨别性回避反应的习得和反转学习过程中，于子宫内接受可卡因（8毫克/千克/天，静脉注射）或生理盐水处理。在习得和反转学习期间，暴露于可卡因的雌性兔子的前扣带回皮质兴奋性训练诱导活动（TIA）减弱，但仅在雄性兔子的反转学习期间出现这种情况。在习得期间，暴露于可卡因的兔子的后扣带回皮质兴奋性TIA降低，而对正负线索的辨别增强。在习得和反转学习期间，暴露于可卡因的兔子的前腹侧丘脑神经元放电减弱。暴露于可卡因的兔子的行为学习正常。其他数据表明，子宫内暴露于可卡因的兔子在使用非显著线索训练时表现出学习缺陷。
