Toll受体介导的果蝇免疫反应需要Dif，一种核因子κB（NF-κB）因子。
Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor.
作者信息
Meng X, Khanuja B S, Ip Y T
机构信息
Program in Molecular Medicine, Department of Cell Biology, and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 USA.
出版信息
Genes Dev. 1999 Apr 1;13(7):792-7. doi: 10.1101/gad.13.7.792.
Abstract
The induction of immunity genes in Drosophila has been proposed to be dependent on Dorsal, Dif, and Relish, the NF-kappaB-related factors. Here we provide genetic evidence that Dif is required for the induction of only a subset of antimicrobial peptide genes. The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin. We also demonstrate that Dif is a downstream component of the Toll signaling pathway in activating the drosomycin expression. These results reveal that individual members of the NF-kappaB family in Drosophila have distinct roles in immunity and development.
摘要
果蝇中免疫基因的诱导被认为依赖于与核因子κB相关的因子背腹因子（Dorsal）、Dif和Relish。在此，我们提供了遗传学证据，表明Dif仅在诱导一部分抗菌肽基因时是必需的。结果显示，在没有背腹因子的情况下，Dif的存在足以介导果蝇霉素（drosomycin）和防御素（defensin）的诱导。我们还证明，在激活果蝇霉素表达过程中，Dif是Toll信号通路的下游组分。这些结果揭示，果蝇中核因子κB家族的各个成员在免疫和发育中具有不同的作用。
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