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Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.酵母钙调神经磷酸酶通过去磷酸化作用调节Crz1p转录因子的核定位。
Genes Dev. 1999 Apr 1;13(7):798-803. doi: 10.1101/gad.13.7.798.
2
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The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner.酵母转录因子 Crz1 通过钙依赖和钙调神经磷酸酶非依赖以及蛋白激酶 A 非依赖的方式被光激活。
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Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae.Tcn1p/Crz1p，一种依赖钙调神经磷酸酶的转录因子，它在酿酒酵母中差异调节基因表达。
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Updating Insights into the Regulatory Mechanisms of Calcineurin-Activated Transcription Factor Crz1 in Pathogenic Fungi.深入了解致病真菌中钙调神经磷酸酶激活转录因子Crz1的调控机制的最新进展
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本文引用的文献

1
The Golgi apparatus plays a significant role in the maintenance of Ca2+ homeostasis in the vps33Delta vacuolar biogenesis mutant of Saccharomyces cerevisiae.高尔基体在酿酒酵母vps33Delta液泡生物发生突变体的Ca2+稳态维持中发挥着重要作用。
J Biol Chem. 1999 Feb 26;274(9):5939-47. doi: 10.1074/jbc.274.9.5939.
2
The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus.受体Msn5将磷酸化的转录因子Pho4输出细胞核。
Nature. 1998 Dec 3;396(6710):482-6. doi: 10.1038/24898.
3
Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.磷酸化作用调控转录因子Pho4与其输入受体Pse1/Kap121之间的结合。
Genes Dev. 1998 Sep 1;12(17):2673-83. doi: 10.1101/gad.12.17.2673.
4
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.一种依赖钙调神经磷酸酶的心肌肥大转录途径。
Cell. 1998 Apr 17;93(2):215-28. doi: 10.1016/s0092-8674(00)81573-1.
5
The transcription factor NF-ATc is essential for cardiac valve formation.转录因子NF-ATc对心脏瓣膜形成至关重要。
Nature. 1998 Mar 12;392(6672):186-90. doi: 10.1038/32426.
6
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.NF-ATc转录因子在心脏瓣膜和间隔形态发生中的作用。
Nature. 1998 Mar 12;392(6672):182-6. doi: 10.1038/32419.
7
Temperature-induced expression of yeast FKS2 is under the dual control of protein kinase C and calcineurin.温度诱导的酵母FKS2表达受蛋白激酶C和钙调神经磷酸酶的双重调控。
Mol Cell Biol. 1998 Feb;18(2):1013-22. doi: 10.1128/MCB.18.2.1013.
8
Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae.Tcn1p/Crz1p，一种依赖钙调神经磷酸酶的转录因子，它在酿酒酵母中差异调节基因表达。
Genes Dev. 1997 Dec 15;11(24):3445-58. doi: 10.1101/gad.11.24.3445.
9
Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast.钙调神经磷酸酶通过CRZ1/TCN1编码的转录因子发挥作用，以调节酵母中的基因表达。
Genes Dev. 1997 Dec 15;11(24):3432-44. doi: 10.1101/gad.11.24.3432.
10
An essential role of the yeast pheromone-induced Ca2+ signal is to activate calcineurin.酵母信息素诱导的Ca2+信号的一个重要作用是激活钙调神经磷酸酶。
Mol Biol Cell. 1997 Feb;8(2):263-77. doi: 10.1091/mbc.8.2.263.

酵母钙调神经磷酸酶通过去磷酸化作用调节Crz1p转录因子的核定位。

Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation.

作者信息

Stathopoulos-Gerontides A, Guo J J, Cyert M S

机构信息

Deptartment of Biological Sciences, Stanford University, Stanford, California 94305-5020 USA.

出版信息

Genes Dev. 1999 Apr 1;13(7):798-803. doi: 10.1101/gad.13.7.798.

DOI:10.1101/gad.13.7.798
PMID:10197980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC316598/
Abstract

Calcineurin, a Ca2+/calmodulin dependent protein phosphatase, regulates Ca2+-dependent processes in a wide variety of cells. In the yeast, Saccharomyces cerevisiae, calcineurin effects Ca2+-dependent changes in gene expression through regulation of the Crz1p transcription factor. We show here that calcineurin dephosphorylates Crz1p and that this results in translocation of Crz1p to the nucleus. We identify a region of Crz1p that is required for calcineurin-dependent regulation of its phosphorylation, localization, and activity, and show that this region has significant sequence simlarity to a portion of NF-AT, a family of mammalian transcription factors whose localization is also regulated by calcineurin. Thus, the mechanism of Ca2+/calcineurin-dependent signaling shows remarkable conservation between yeast and mammalian cells.

摘要

钙调神经磷酸酶是一种依赖于Ca2+/钙调蛋白的蛋白磷酸酶，可调节多种细胞中依赖Ca2+的过程。在酵母酿酒酵母中，钙调神经磷酸酶通过调节Crz1p转录因子来影响基因表达中依赖Ca2+的变化。我们在此表明，钙调神经磷酸酶使Crz1p去磷酸化，这导致Crz1p易位至细胞核。我们鉴定出Crz1p的一个区域，该区域对于钙调神经磷酸酶依赖的其磷酸化、定位和活性调节是必需的，并表明该区域与NF-AT的一部分具有显著的序列相似性，NF-AT是一类哺乳动物转录因子家族，其定位也受钙调神经磷酸酶调节。因此，Ca2+/钙调神经磷酸酶依赖的信号传导机制在酵母和哺乳动物细胞之间表现出显著的保守性。