Meddings J B, Jarand J, Urbanski S J, Hardin J, Gall D G
Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
Am J Physiol. 1999 Apr;276(4):G951-7. doi: 10.1152/ajpgi.1999.276.4.G951.
The BB rat spontaneously develops autoimmune diabetes. Feeding these animals a hydrolyzed casein diet significantly reduces the incidence of this disease, suggesting that a dietary antigen is involved in the pathogenesis of this disease. In other syndromes associated with luminal antigens, including celiac and Crohn's disease, increased intestinal permeability has been suggested to play an etiological role. Therefore, the objective of this study was to evaluate whether increased permeability was also present in BB rats before disease development. By measuring gastrointestinal permeability, in animals on a regular or hydrolyzed casein diet, we were able to demonstrate that increased gastric and small intestinal permeability appeared before the development of both insulitis and clinical diabetes. Although hydrolysis of dietary protein significantly reduced the incidence of diabetes, it did not alter the small intestinal permeability abnormality, suggesting that this is an early event. Increased permeability appears to have an early role in the genesis of several immunological diseases and may represent a common event in these diseases.
BB大鼠会自发发展为自身免疫性糖尿病。给这些动物喂食水解酪蛋白饮食可显著降低该疾病的发病率，这表明一种饮食抗原参与了该疾病的发病机制。在其他与腔内抗原相关的综合征中，包括乳糜泻和克罗恩病，肠通透性增加被认为起到病因学作用。因此，本研究的目的是评估在疾病发展之前BB大鼠是否也存在通透性增加的情况。通过测量常规饮食或水解酪蛋白饮食的动物的胃肠通透性，我们能够证明胃和小肠通透性增加出现在胰岛炎和临床糖尿病发展之前。虽然饮食蛋白的水解显著降低了糖尿病的发病率，但它并未改变小肠通透性异常，这表明这是一个早期事件。通透性增加似乎在几种免疫性疾病的发生中起早期作用，并且可能是这些疾病中的一个常见现象。
