Gurski M R, Gonzalez E, Brown E G
Department of Pediatrics, Loiusiana State University Medical Center, Shreveport 71130-3932, USA.
J Investig Med. 1999 Mar;47(3):128-33.
Platelet-derived growth factor (PDGF) has an important role in cellular function, proliferation, and angiogenesis. It is also associated with tissue injury and repair, and its involvement in atherosclerosis has been studied extensively. Tissue injury is also found in pre-eclampsia (PRE). The morphological and physiological changes that are taking place in the PRE placenta may be associated with this growth factor. The objective of this study was to determine if PDGF-AA and its alpha receptor are present in the cells and vessels of normotensive (NORM) and PRE placentas at term.
Placental tissue was obtained from 6 preeclamptic and 8 normotensive women. Gestational age ranged from 38-42 weeks. Deliveries were either vaginal (vag, n = 10) or c-section (c-sec, n = 4). Tissue samples were analyzed for PDGF-AA by immunocytochemistry.
PDGF-AA and the alpha receptor were present in both NORM and PRE placentas. Immunoreactive staining revealed PDGF-AA and its receptor in the intimal/endothelial layer of fetal vessels and the trophoblastic layer. Staining intensity was greater in preeclamptic tissue when obliterative endarteritis was present.
In pre-eclampsia, PDGF-AA may play a role in the restructuring of the fetoplacental vasculature, in particular when there is inflammation of the vascular intimal layer, as found in obliterative endarteritis. Increased staining in the trophoblast layer in patients with obliterative endarteritis also may be indicative of more widespread damage throughout the placenta itself, and PDGF-AA may play a significant role in the repair of this damage.
血小板衍生生长因子（PDGF）在细胞功能、增殖和血管生成中起重要作用。它还与组织损伤和修复有关，并且其在动脉粥样硬化中的作用已得到广泛研究。子痫前期（PRE）也存在组织损伤。PRE胎盘发生的形态和生理变化可能与这种生长因子有关。本研究的目的是确定足月正常血压（NORM）和PRE胎盘的细胞和血管中是否存在PDGF-AA及其α受体。
从6例子痫前期患者和8例血压正常的女性获取胎盘组织。孕周为38 - 42周。分娩方式为阴道分娩（vag，n = 10）或剖宫产（c-sec，n = 4）。通过免疫细胞化学分析组织样本中的PDGF-AA。
NORM和PRE胎盘均存在PDGF-AA及其α受体。免疫反应性染色显示胎儿血管内膜/内皮细胞层和滋养层中有PDGF-AA及其受体。当存在闭塞性动脉内膜炎时，子痫前期组织中的染色强度更大。
在子痫前期，PDGF-AA可能在胎儿胎盘血管系统的重构中起作用，特别是当存在血管内膜炎症时，如在闭塞性动脉内膜炎中所见。闭塞性动脉内膜炎患者滋养层染色增加也可能表明整个胎盘本身存在更广泛的损伤，并且PDGF-AA可能在这种损伤的修复中起重要作用。
