Pérot C, Bougaran J, Boccon-Gibod L, Störkel S, Leverger G, van den Akker J, Taillemite J L, Couturier J
Laboratoire de Cytogénétique, Hôpital Saint-Antoine, Paris, France.
Cancer Genet Cytogenet. 1999 Apr;110(1):54-6. doi: 10.1016/s0165-4608(98)00181-2.
Two cases of papillary renal cell carcinoma (RCC) with a karyotype 46,X,t(X;1)(p11.2;q21) in two female patients aged 9 and 29 years are reported. These observations, and the review of the 17 reported cases with a translocation at band Xp11 confirm that this abnormality delineates a clinicopathological entity within the classical papillary RCC, characterized by the early age of occurrence and, probably, distinct histological features. Including these two new female cases, the sex ratio in cases with t(X;1) appears similar to that observed in the other papillary RCC.
报道了两例核型为46,X,t(X;1)(p11.2;q21)的乳头状肾细胞癌（RCC），患者为两名分别9岁和29岁的女性。这些观察结果，以及对17例报道的Xp11带发生易位的病例的回顾证实，这种异常在经典乳头状RCC中界定了一种临床病理实体，其特征为发病年龄早，且可能具有独特的组织学特征。包括这两例新的女性病例在内，t(X;1)病例中的性别比似乎与其他乳头状RCC中观察到的相似。
