Osadchiĭ O E, Pokrovskiĭ V M
Department of Normal Physiology, Kuban Medical Academy, Krasnodar, Russia.
Eksp Klin Farmakol. 1999 Jan-Feb;62(1):24-7.
In cat experiments the effect of methenkephalin on the heart rate, on the chronotropic effect of the vagus and its components--tonic and synchronizing was compared with the influence of the selective agonists and antagonists mu- and delta-opiate receptors. The influence of methenkephalin on the initial heart rate and the synchronizing component of the vagal chronotropic effect was found to be realized through excitation of the delta-opiate receptors. The modulating effect of methenkephalin on the expression of the inhibiting tonic action of the vagus was mediated both by the mu- and delta-opiate receptors.
