Osadchiĭ O E, Pokrovskiĭ V M
Patol Fiziol Eksp Ter. 1998 Jan-Mar(1):32-5.
Administration of met-enkephalin to anesthetized cats promoted inhibition of the heart rate, weakening of the vagus chronotropic effect with changes of its functional structure consisting of suppression of the inhibitory tonic effect and potentiating synchronizing component. The comparison of the peptide's vagotropic action in the initial conditions versus in the block of the sympathetic nervous system induced by obsidan, guanethidine or reserpine allows the conclusion that the effect of met-enkephalin on the baseline heart rate, strength of the vagus chronotropic effect and its tonic component stems from weakened sympathetic effects on the heart, whereas potentiation of the synchronizing vagus component is achieved through the peptides effects in the limits of vagus regulation system.
给麻醉的猫注射甲硫氨酸脑啡肽会促进心率抑制，减弱迷走神经变时效应，并改变其功能结构，包括抑制抑制性紧张性效应和增强同步性成分。比较该肽在初始条件下与由胍乙啶、胍那苄或利血平诱导的交感神经系统阻断情况下的向迷走神经作用，可以得出结论：甲硫氨酸脑啡肽对基础心率、迷走神经变时效应强度及其紧张性成分的影响源于交感神经对心脏的作用减弱，而迷走神经同步性成分的增强是通过该肽在迷走神经调节系统范围内的作用实现的。
