Egi Y, Fujimoto H, Kondo M, Shirota T, Hayashi T
Third Department of Internal Medicine, Tokyo Medical University Hospital.
Rinsho Ketsueki. 1999 Feb;40(2):140-4.
We report a case of Burkitt's lymphoma originating in gluteal muscle tissue. A 61-year-old Japanese man was admitted to our hospital due to painful swelling of the left femur and gluteal region in October 1996. A laboratory examination disclosed elevated levels of serum lactate dehydrogenase and soluble interleukin 2 receptor. Gallium scintigraphy demonstrated accumulations in the left femur and gluteal region. Magnetic resonance imaging yielded intense signals and disclosed swelling of muscle tissue in the same region. Pathological examination of biopsy specimens from the left femur revealed a starry-sky pattern, and a chromosomal analysis revealed t(2;8)(p11;q24). Heightened concentrations of antibody for Epstein-Barr virus were not detected. Non-African type Burkitt's lymphoma was diagnosed on the basis of these findings. CHOP therapy and irradiation of the affected region were initially effective, but the disease eventually became resistant to treatment. The patient died of cerebral hemorrhage. As far as we know, this is the first report in Japan of Burkitt's lymphoma originating in muscle tissue.
我们报告一例起源于臀肌组织的伯基特淋巴瘤。一名61岁的日本男性于1996年10月因左股骨和臀部区域疼痛性肿胀入住我院。实验室检查显示血清乳酸脱氢酶和可溶性白细胞介素2受体水平升高。镓闪烁显像显示左股骨和臀部区域有放射性聚集。磁共振成像显示强烈信号，并揭示同一区域肌肉组织肿胀。对左股骨活检标本的病理检查显示有满天星图案，染色体分析显示t(2;8)(p11;q24)。未检测到爱泼斯坦-巴尔病毒抗体浓度升高。根据这些发现诊断为非非洲型伯基特淋巴瘤。CHOP疗法和对患区的放射治疗最初有效，但疾病最终对治疗产生耐药性。患者死于脑出血。据我们所知，这是日本首例起源于肌肉组织的伯基特淋巴瘤报告。
