Lania L, Majello B, Napolitano G
Department of Genetics, Molecular and General Biology, University of Naples Federico II, Italy.
J Cell Physiol. 1999 May;179(2):134-41. doi: 10.1002/(SICI)1097-4652(199905)179:2<134::AID-JCP3>3.0.CO;2-O.
In eukaryotes, progression of the cell cycle is associated with periodic transcription activation/repression of growth-regulatory genes. We summarize here current knowledge and views on the role of critical cell-cycle regulators such as the retinoblastoma pocket family members and cyclin-dependent kinases in the regulation of gene transcription. In particular, we discuss here the role of specific cyclin-dependent kinase complexes in the regulation of basal transcription. Although the functional connections between transcription and cell-cycle regulators is far from being understood, recent progress has been made in connecting cell-cycle progression to dedicated components of the RNA polymerase II transcription apparatus complex.
在真核生物中，细胞周期的进程与生长调节基因的周期性转录激活/抑制相关。我们在此总结了关于关键细胞周期调节因子（如视网膜母细胞瘤口袋家族成员和细胞周期蛋白依赖性激酶）在基因转录调控中作用的当前知识和观点。特别是，我们在此讨论特定细胞周期蛋白依赖性激酶复合物在基础转录调控中的作用。尽管转录与细胞周期调节因子之间的功能联系远未被理解，但在将细胞周期进程与RNA聚合酶II转录装置复合物的特定成分联系起来方面已取得了最新进展。
