Napolitano Giuliana, Lania Luigi, Majello Barbara
Department of Biology, University of Naples Federico II, Naples, Italy.
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Italy.
Biomed Res Int. 2014;2014:643805. doi: 10.1155/2014/643805. Epub 2014 Feb 19.
P-TEFb is a transcriptional factor that specifically regulates the elongation step of RNA polymerase II-dependent transcription and its activity strictly required for Human Immunodeficiency Virus (HIV) infection and during cardiac differentiation. P-TEFb role has emerged as a crucial regulator of transcription elongation and its activity found finely tuned in vivo at transcriptional level as well as posttranscriptionally by dynamic association with different multisubunit molecular particles. Both physiological and pathological cellular signals rapidly converge on P-TEFb regulation by modifying expression and activity of the complex to allow cells to properly respond to different stimuli. In this review we will give a panoramic view on P-TEFb regulation by noncoding RNAs in both physiological and pathological conditions.
正性转录延伸因子b（P-TEFb）是一种转录因子，它特异性地调节RNA聚合酶II依赖性转录的延伸步骤，其活性是人类免疫缺陷病毒（HIV）感染以及心脏分化过程中严格必需的。P-TEFb的作用已成为转录延伸的关键调节因子，并且在体内其活性在转录水平以及通过与不同的多亚基分子颗粒动态结合在转录后水平上都得到了精细调节。生理和病理细胞信号都通过改变复合物的表达和活性迅速汇聚到对P-TEFb的调节上，以使细胞能够对不同刺激做出适当反应。在这篇综述中，我们将全景式地介绍在生理和病理条件下非编码RNA对P-TEFb的调节。
