钙调神经磷酸酶α在海马突触去增强中的选择性作用。
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.
作者信息
Zhuo M, Zhang W, Son H, Mansuy I, Sobel R A, Seidman J, Kandel E R
机构信息
Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4650-5. doi: 10.1073/pnas.96.8.4650.
Abstract
Pharmacological studies have suggested that long-term potentiation (LTP) and long-term depression (LTD) and depotentiation, three forms of synaptic plasticity in the hippocampus, require the activity of the phosphatase calcineurin. At least two different isoforms of calcineurin are found in the central nervous system. To investigate whether all of these forms of synaptic plasticity require the same isoforms of calcineurin, we have examined LTD, depotentiation, and LTP in mice lacking the predominant calcineurin isoform in the central nervous system, Aalpha-/- mice. Depotentiation was abolished completely whereas neither LTD nor LTP were affected. These studies provide genetic evidence that the Aalpha isoform of calcineurin is important for the reversal of LTP in the hippocampus and indicate that depotentiation and LTD operate through somewhat different molecular mechanisms.
摘要
药理学研究表明，长时程增强（LTP）、长时程抑制（LTD）和去增强作用，海马体中突触可塑性的三种形式，需要磷酸酶钙调神经磷酸酶的活性。在中枢神经系统中发现了至少两种不同的钙调神经磷酸酶同工型。为了研究是否所有这些形式的突触可塑性都需要相同的钙调神经磷酸酶同工型，我们检测了缺乏中枢神经系统中主要钙调神经磷酸酶同工型的小鼠（Aalpha-/-小鼠）的LTD、去增强作用和LTP。去增强作用完全消失，而LTD和LTP均未受影响。这些研究提供了遗传学证据，表明钙调神经磷酸酶的Aalpha同工型对海马体中LTP的逆转很重要，并表明去增强作用和LTD通过 somewhat 不同的分子机制起作用。 （注：原文中“somewhat”疑有误，结合语境这里应是“some”）
相似文献
1
A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.钙调神经磷酸酶α在海马突触去增强中的选择性作用。
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4650-5. doi: 10.1073/pnas.96.8.4650.
2
LTD, LTP, and the sliding threshold for long-term synaptic plasticity.长时程抑制、长时程增强与长期突触可塑性的滑动阈值
Hippocampus. 1996;6(1):35-42. doi: 10.1002/(SICI)1098-1063(1996)6:1<35::AID-HIPO7>3.0.CO;2-6.
3
A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.蛋白磷酸酶1、2A和2B在小脑长时程增强中的作用。
J Neurosci. 2005 Nov 16;25(46):10768-72. doi: 10.1523/JNEUROSCI.2876-05.2005.
4
Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.毒蕈碱型长时程抑制与CA3-CA1突触处电诱导的长时程增强和抑制共存。
J Neurophysiol. 2006 Dec;96(6):3114-21. doi: 10.1152/jn.00144.2006. Epub 2006 Sep 27.
5
Homosynaptic LTD and depotentiation: do they differ in name only?
Hippocampus. 1996;6(1):24-9. doi: 10.1002/(SICI)1098-1063(1996)6:1<24::AID-HIPO5>3.0.CO;2-7.
6
Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase.丝氨酸/苏氨酸磷酸酶在 LTP 中的作用：二选一还是二选二——蛋白合成抑制剂诱导早期相受损
Int J Mol Sci. 2021 May 4;22(9):4857. doi: 10.3390/ijms22094857.
7
Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus.5-羟色胺对Ca(2+)内流途径的选择性调节作用调控着海马体中的突触长期可塑性。
Brain Res. 2005 Mar 10;1037(1-2):187-93. doi: 10.1016/j.brainres.2005.01.001.
8
Different phosphatase-dependent mechanisms mediate long-term depression and depotentiation of long-term potentiation in mouse hippocampal CA1 area.不同的磷酸酶依赖性机制介导小鼠海马CA1区的长时程抑制以及长时程增强的去增强作用。
Eur J Neurosci. 2003 Sep;18(5):1279-85. doi: 10.1046/j.1460-9568.2003.02831.x.
9
Synaptic plasticity: going through phases with LTP.突触可塑性：与长时程增强一同经历不同阶段。
Curr Biol. 1998 May 7;8(10):R350-2. doi: 10.1016/s0960-9822(98)70219-2.
10
[The role of calcineurin on the induction of synaptic plasticity].[钙调神经磷酸酶在突触可塑性诱导中的作用]
Nihon Shinkei Seishin Yakurigaku Zasshi. 2000 Nov;20(5):189-98.
引用本文的文献
1
Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus.强直性激活素信号主要在背侧海马体中塑造CA1神经元的细胞和突触特性。
iScience. 2023 Sep 21;26(10):108001. doi: 10.1016/j.isci.2023.108001. eCollection 2023 Oct 20.
2
Calcium Dyshomeostasis Drives Pathophysiology and Neuronal Demise in Age-Related Neurodegenerative Diseases.钙动态失衡驱动与年龄相关的神经退行性疾病的病理生理学和神经元死亡。
Int J Mol Sci. 2023 Aug 26;24(17):13243. doi: 10.3390/ijms241713243.
3
Calcineurin inhibitor (CNI)-associated skin cancers: New insights on exploring mechanisms by which CNIs downregulate DNA repair machinery.钙调磷酸酶抑制剂（CNI）相关皮肤癌：探索 CNI 下调 DNA 修复机制的新见解。
Photodermatol Photoimmunol Photomed. 2020 Nov;36(6):433-440. doi: 10.1111/phpp.12600. Epub 2020 Aug 27.
4
Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats.深部脑刺激可使点燃大鼠的谷氨酸能和 GABA 能突触传递和可塑性恢复至正常水平。
PLoS One. 2019 Nov 7;14(11):e0224834. doi: 10.1371/journal.pone.0224834. eCollection 2019.
5
Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats.长时程增强的去极化与成年大鼠海马中表位特异性 tau 过度/低磷酸化有关。
J Mol Neurosci. 2019 Feb;67(2):193-203. doi: 10.1007/s12031-018-1224-x. Epub 2018 Nov 29.
6
Calcineurin-AKAP interactions: therapeutic targeting of a pleiotropic enzyme with a little help from its friends.钙调神经磷酸酶-AKAP 相互作用：一种多功能酶的治疗靶点，其朋友助其一臂之力。
J Physiol. 2020 Jul;598(14):3029-3042. doi: 10.1113/JP276756. Epub 2018 Dec 26.
7
Pin1 mediates Aβ-induced dendritic spine loss.Pin1 介导 Aβ 诱导的树突棘缺失。
Sci Signal. 2018 Mar 20;11(522):eaap8734. doi: 10.1126/scisignal.aap8734.
8
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.PERK 的局部抑制增强记忆并逆转认知和神经元功能与年龄相关的恶化。
J Neurosci. 2018 Jan 17;38(3):648-658. doi: 10.1523/JNEUROSCI.0628-17.2017. Epub 2017 Dec 1.
9
Neurobiology of fear and specific phobias.恐惧与特定恐惧症的神经生物学
Learn Mem. 2017 Aug 16;24(9):462-471. doi: 10.1101/lm.044115.116. Print 2017 Sep.
10
The Impact of Electrographic Seizures on Developing Hippocampal Dendrites Is Calcineurin Dependent.电发作对发育中海马树突的影响依赖于钙调神经磷酸酶。
eNeuro. 2017 Apr 28;4(2). doi: 10.1523/ENEURO.0014-17.2017. eCollection 2017 Mar-Apr.
本文引用的文献
1
Low-frequency stimulation erases LTP through an NMDA receptor-mediated activation of protein phosphatases.低频刺激通过NMDA受体介导的蛋白磷酸酶激活来消除长时程增强。
Learn Mem. 1994 Jul-Aug;1(2):129-39.
2
Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.钙调神经磷酸酶抑制的一种新型长期增强中间阶段的遗传和药理学证据。
Cell. 1998 Jan 9;92(1):25-37. doi: 10.1016/s0092-8674(00)80896-x.
3
Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells.两种不同形式的长时程抑制共存于海马体CA1区锥体细胞中。
Neuron. 1997 Jun;18(6):969-82. doi: 10.1016/s0896-6273(00)80336-0.
4
Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A.免疫抑制药物FK506、雷帕霉素和环孢素A的非免疫抑制类似物的神经营养作用。
Nat Med. 1997 Apr;3(4):421-8. doi: 10.1038/nm0497-421.
5
Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain.哺乳动物大脑中突触可塑性、活动依赖性神经发育、学习和记忆的分子遗传学分析。
Annu Rev Neurosci. 1997;20:157-84. doi: 10.1146/annurev.neuro.20.1.157.
6
FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus.FK506，一种钙调神经磷酸酶抑制剂，可抑制大鼠海马体中长时程增强效应的诱导。
Neurosci Lett. 1996 Feb 23;205(2):103-6. doi: 10.1016/0304-3940(96)12384-3.
7
8
Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region.突触后环磷酸腺苷（cAMP）信号通路控制海马CA1区早期长时程增强（LTP）。
Neuron. 1995 Dec;15(6):1403-14. doi: 10.1016/0896-6273(95)90018-7.
9
Only 'de novo' long-term depression (LTD) in the rat hippocampus in vitro is blocked by the same low concentration of FK506 that blocks LTD in the visual cortex.仅大鼠海马体体外“从头开始”的长期抑制（LTD）会被与阻断视觉皮层LTD相同的低浓度FK506所阻断。
Brain Res. 1995 Dec 24;705(1-2):241-46. doi: 10.1016/0006-8993(95)01168-4.
10
Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.
Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1571-6. doi: 10.1073/pnas.93.4.1571.
Zotero 插件