Dahlmanns Marc, Valero-Aracama Maria Jesus, Dahlmanns Jana Katharina, Zheng Fang, Alzheimer Christian
Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
iScience. 2023 Sep 21;26(10):108001. doi: 10.1016/j.isci.2023.108001. eCollection 2023 Oct 20.
Dorsal and ventral hippocampus serve different functions in cognition and affective behavior, but the underpinnings of this diversity at the cellular and synaptic level are not well understood. We found that the basal level of activin A, a member of the TGF-β family, which regulates hippocampal circuits in a behaviorally relevant fashion, is much higher in dorsal than in ventral hippocampus. Using transgenic mice with a forebrain-specific disruption of activin receptor signaling, we identified the pronounced dorsal-ventral gradient of activin A as a major factor determining the distinct neurophysiologic signatures of dorsal and ventral hippocampus, ranging from pyramidal cell firing, tuning of frequency-dependent synaptic facilitation, to long-term potentiation (LTP), long-term depression (LTD), and de-potentiation. Thus, the strong activin A tone in dorsal hippocampus appears crucial to establish cellular and synaptic phenotypes that are tailored specifically to the respective network operations in dorsal and ventral hippocampus.
背侧海马体和腹侧海马体在认知和情感行为中发挥着不同的功能，但在细胞和突触水平上这种差异的基础尚未得到充分理解。我们发现，转化生长因子-β（TGF-β）家族成员激活素A的基础水平，以与行为相关的方式调节海马回路，在背侧海马体中比在腹侧海马体中要高得多。利用在前脑特异性破坏激活素受体信号的转基因小鼠，我们确定激活素A明显的背腹梯度是决定背侧和腹侧海马体不同神经生理特征的主要因素，这些特征包括锥体细胞放电、频率依赖性突触易化的调节、长期增强（LTP）、长期抑制（LTD）和去增强。因此，背侧海马体中强烈的激活素A信号对于建立专门针对背侧和腹侧海马体各自网络运作的细胞和突触表型似乎至关重要。
