Müller N, Riedel M, Hadjamu M, Schwarz M J, Ackenheil M, Gruber R
Psychiatric Hospital, Ludwig-Maximillian University, Munich, Germany.
Am J Psychiatry. 1999 Apr;156(4):634-6.
The authors estimated the expression of adhesion molecule receptors (VLA-4 and LFA-1) on T helper (CD4+) and T suppressor/cytotoxic (CD8+) lymphocytes in schizophrenic patients before and during antipsychotic treatment and studied the relationship of these subpopulations to CSF measures and blood-brain barrier permeability.
Blood was drawn from hospitalized patients with schizophrenia before (N = 45) and after (N = 22) neuroleptic treatment and from an age-matched comparison group (N = 41). Lumbar punctures were performed on 32 of the schizophrenic patients.
During antipsychotic treatment there were significant increases in the percentage of VLA-4+/CD4+ and VLA-4+/CD8+ cells. VLA-4+/CD4+ and LFA-1+/CD4+ cells were both closely related to disturbance of the blood-brain barrier. Higher values for VLA-4+/CD4+ and LFA-1+/CD4+ cells were found in patients with a disturbed blood-brain barrier.
The findings suggest that adhesion molecules are involved in immunoregulation between the central nervous system and the peripheral immune system in schizophrenia.
作者评估了精神分裂症患者在抗精神病治疗前及治疗期间，辅助性T细胞（CD4+）和抑制性/细胞毒性T细胞（CD8+）上黏附分子受体（VLA-4和LFA-1）的表达情况，并研究了这些亚群与脑脊液指标及血脑屏障通透性之间的关系。
采集了住院精神分裂症患者在接受抗精神病药物治疗前（N = 45）、治疗后（N = 22）的血液样本，以及年龄匹配的对照组（N = 41）的血液样本。对32例精神分裂症患者进行了腰椎穿刺。
在抗精神病治疗期间，VLA-4+/CD4+和VLA-4+/CD8+细胞的百分比显著增加。VLA-4+/CD4+和LFA-1+/CD4+细胞均与血脑屏障的紊乱密切相关。血脑屏障紊乱的患者中，VLA-4+/CD4+和LFA-1+/CD4+细胞的值更高。
研究结果表明，黏附分子参与了精神分裂症中枢神经系统与外周免疫系统之间的免疫调节。
