Baskak Seda Celik, Ozsan Hüseyin, Baskak Bora, Devrimci Ozgüven Halise, Kinikli Gülay
Madalyon Psikiyatri Merkezi, Ankara U Tip Fak., Psikiyatri AD, Ankara.
Turk Psikiyatri Derg. 2008 Spring;19(1):5-12.
Immune system abnormalities in schizophrenia have been previously studied. According to the present point of view, an infection or autoimmune process might be occurring in the form of cellular and/or humoral immune system abnormalities in schizophrenia. Furthermore, several effects of antipsychotic medication on the immunological profile of schizophrenic patients have been demonstrated. The present study aimed to compare the total T-lymphocytes level and the T-lymphocyte subset ratios in schizophrenia patients not treated with antipsychotics and healthy controls. The relationship between disease duration, symptom severity, and treatment response and T-lymphocyte profiles were investigated.
The study included 14 patients (11 antipsychotic naive, 3 antipsychotic free for at least 6 months) diagnosed with schizophrenia or schizophreniform disorder that were compared to age- and sex-matched healthy controls in terms of the total T-lymphocytes level and T-lymphocyte subset ratios using flow-cytometry. The relationship of the T-lymphocyte profiles, to disease duration and treatment response was investigated.
The groups were not different in terms of total T-lymphocytes level and T-lymphocyte subset ratios; however, the antipsychotic naive patients and the group with disease duration < 2 years had lower rates of T8-lymphocytes. Total T-lymphocytes and the T8-lymphocyte ratio increased after treatment. Clinical improvement was correlated with total T-lymphocytes and the T4-lymphocyte subset ratio.
Cellular immune system abnormalities in schizophrenia may be intrinsic factors. Changes in the cellular immune system are associated with treatment response and might be candidates for biological markers.
此前已对精神分裂症患者的免疫系统异常进行过研究。按照目前的观点，在精神分裂症中，感染或自身免疫过程可能以细胞和/或体液免疫系统异常的形式出现。此外，已证实抗精神病药物对精神分裂症患者的免疫特征有多种影响。本研究旨在比较未接受抗精神病药物治疗的精神分裂症患者与健康对照者的总T淋巴细胞水平及T淋巴细胞亚群比例。研究了病程、症状严重程度、治疗反应与T淋巴细胞谱之间的关系。
该研究纳入了14例被诊断为精神分裂症或分裂样障碍的患者（11例未用过抗精神病药物，3例至少6个月未使用抗精神病药物），通过流式细胞术比较其与年龄和性别匹配的健康对照者在总T淋巴细胞水平及T淋巴细胞亚群比例方面的差异。研究了T淋巴细胞谱与病程及治疗反应之间的关系。
两组在总T淋巴细胞水平及T淋巴细胞亚群比例方面无差异；然而，未用过抗精神病药物的患者及病程<2年的组T8淋巴细胞比例较低。治疗后总T淋巴细胞及T8淋巴细胞比例升高。临床改善与总T淋巴细胞及T4淋巴细胞亚群比例相关。
精神分裂症中的细胞免疫系统异常可能是内在因素。细胞免疫系统的变化与治疗反应相关，可能是生物学标志物的候选对象。
