James A L, Carroll N, De Klerk N, Elliott J, Musk A W, Ryan G
Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia.
Respirology. 1998 Dec;3(4):241-5. doi: 10.1111/j.1440-1843.1998.tb00129.x.
To compare the perception of airway narrowing of nonasthmatic subjects with those having wheeze or mild asthma (doctor-diagnosed), the relationship between FEV1 and breathlessness was examined in 123 subjects from a general population sample. Scores for breathlessness, using the Borg scale, were recorded before and after inhaling incremental doses of methacholine to a maximal dose of 196 mcmol or a maximum change in FEV1 of 50%. A history of asthma symptoms, including wheeze in the previous 12 months, and doctor-diagnosed asthma was obtained by questionnaire. At any given level of FEV1 there was wide variation in Borg scores between subjects, however median Borg scores and the mean slope of Borg score on FEVI was greater in the asthmatic subjects or those with wheeze compared with nonasthmatic subjects or those without wheeze. In both nonasthmatic and asthmatic subjects, those with airway hyperresponsiveness had increased maximum symptom scores and maximum changes in FEVI, but similar Borg scores relative to change in FEVI, compared with those without hyperresponsiveness. We conclude that the perception of mild and moderate degrees of airway narrowing varies widely between individuals but is increased in subjects with a history of mild asthma or wheeze in the last 12 months, independently of airway responsiveness.
为比较无哮喘受试者与有喘息或轻度哮喘（医生诊断）受试者对气道狭窄的感知，在一个普通人群样本的123名受试者中研究了第一秒用力呼气容积（FEV1）与呼吸困难之间的关系。使用博格量表记录在吸入递增剂量的乙酰甲胆碱直至最大剂量196微摩尔或FEV1最大变化50%之前和之后的呼吸困难评分。通过问卷调查获取哮喘症状史，包括过去12个月内的喘息情况，以及医生诊断的哮喘。在任何给定的FEV1水平上，受试者之间的博格评分差异很大，然而，与无哮喘或无喘息的受试者相比，哮喘受试者或有喘息的受试者的博格评分中位数以及博格评分相对于FEV1的平均斜率更大。在无哮喘和哮喘受试者中，与无气道高反应性的受试者相比，有气道高反应性的受试者具有更高的最大症状评分和FEV1的最大变化，但相对于FEV1变化的博格评分相似。我们得出结论，个体之间对轻度和中度气道狭窄的感知差异很大，但在过去12个月内有轻度哮喘或喘息史的受试者中有所增加，与气道反应性无关。
