Chiplonkar S A, Agte V V, Tarwadi K V, Kavadia R
Biometry and Nutrition Group, Agharkar Research Institute, Pune, India.
Biol Trace Elem Res. 1999 Mar;67(3):249-56. doi: 10.1007/BF02784424.
With a standardized protocol under simulated gastrointestinal conditions, 65Zn and 59Fe dialyzability was measured for 38 diets from 7 different published studies on human absorption. The compositions of these diets were available in the form of the amounts of food ingredients used for breakfast, lunch, and dinner. Considering each of these types as a separate meal, percent dialyzability was measured. The weighted average of breakfast, lunch, dinner, and snacks, if any, was taken to represent the entire day's bioavailability. The correlation between in vitro percent dialyzability and reported human absorption was 0.92 for zinc and 0.96 for iron and both were statistically significant (p = 0.0001). The prediction equations for zinc and iron were obtained as y = -0.7718 + 1.1038x and y = 0.3197 + 0.9084x, respectively. This indicated that in vitro dialyzability using the meal approach can be used as an index with good discriminating power for different levels of human absorption.
在模拟胃肠道条件下采用标准化方案，对来自7项不同已发表的关于人体吸收的研究中的38种饮食进行了65锌和59铁的透析率测定。这些饮食的组成以早餐、午餐和晚餐所用食物成分的量的形式提供。将每种类型视为一顿单独的餐食，测定透析率百分比。早餐、午餐、晚餐以及（如有）零食的加权平均值被用来代表一整天的生物利用度。体外透析率百分比与报道的人体吸收率之间的相关性，锌为0.92，铁为0.96，两者均具有统计学显著性（p = 0.0001）。锌和铁的预测方程分别为y = -0.7718 + 1.1038x和y = 0.3197 + 0.9084x。这表明使用餐食法的体外透析率可作为对不同人体吸收水平具有良好区分能力的指标。
