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本文引用的文献

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A syndrome resembling progeria: A review of two cases.一种类似早老症的综合征:两例病例综述。
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GIANT PIGMENTED NEVI, MELANOMA, AND LEPTOMENINGEAL MELANOCYTOSIS: A CLINICAL AND HISTOPATHOLOGICAL STUDY.巨大色素痣、黑色素瘤与柔脑膜黑色素细胞增多症:一项临床与组织病理学研究
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Neurofibromatosis type 1 (NF1): a protein truncation assay yielding identification of mutations in 73% of patients.1型神经纤维瘤病(NF1):一种蛋白质截短检测方法可鉴定出73%患者的突变。
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Neurology of the vasculitides and connective tissue diseases.血管炎和结缔组织病的神经学
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Consequences of the delayed diagnosis of ataxia-telangiectasia.共济失调毛细血管扩张症延迟诊断的后果。
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Simultaneous ischemic and hemorrhagic lesions of the brain detected by CT scan in a patient with thrombotic thrombocytopenic purpura.在一名血栓性血小板减少性紫癜患者中,CT扫描检测到脑部同时存在缺血性和出血性病变。
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Magnetic resonance imaging lesion analysis in neurofibromatosis type 1.1型神经纤维瘤病的磁共振成像病变分析
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Anatomy of the shaken baby syndrome.摇晃婴儿综合征的解剖学
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神经病学与皮肤。

Neurology and the skin.

作者信息

Hurko O, Provost T T

机构信息

Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):417-30. doi: 10.1136/jnnp.66.4.417.

DOI:10.1136/jnnp.66.4.417
PMID:10201411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1736315/
Abstract

As knowledge of pathophysiology grows, so does the refinement of diagnoses. Sometimes increased knowledge permits consolidation and unification. Unfortunately, at our present level of understanding, it usually demands proliferation of diagnostic categories. As tedious as this diagnostic splintering may seem, such is the price currently exacted of both the investigator and the clinician who seek to optimise management. Increased diagnostic refinement often requires inquiry into matters outside the bounds of one's specialty. Most often we turn to the radiologist or to the laboratory to narrow the differential diagnosis generated from the history and neurological examination. As we have shown, a useful intermediate step is extension of the physical examination to organs such as the skin, which are not the traditional preserve of the neurologist. That any text could confer the sophistication required for expert dermatological diagnosis is an unrealistic expectation. However, we hope that this review will encourage careful examination of the skin, hair, and nails by the neurological practitioner, with consideration of referral to a dermatologist when greater expertise is required.

摘要

随着病理生理学知识的增长,诊断也日益精细化。有时知识的增加会促成诊断的整合与统一。不幸的是,就我们目前的理解水平而言,这通常需要增加诊断类别。尽管这种诊断的细化看似繁琐,但这是目前寻求优化治疗的研究者和临床医生所要付出的代价。诊断的进一步细化往往需要探究超出自身专业范围的问题。大多数情况下,我们会求助于放射科医生或实验室,以缩小根据病史和神经系统检查得出的鉴别诊断范围。正如我们所表明的,一个有用的中间步骤是将体格检查扩展到诸如皮肤等器官,而皮肤并非神经科医生的传统检查范畴。指望任何文本都能提供专家级皮肤诊断所需的专业知识是不切实际的期望。然而,我们希望这篇综述能鼓励神经科从业者仔细检查皮肤、毛发和指甲,在需要更高专业知识时考虑转诊给皮肤科医生。