Kubba A K, Dallal H, Haydon G H, Hayes P C, Palmer K R
Western General Hospital, and The Centre for Liver and Digestive Diseases, Royal Infirmary of Edinburgh, Scotland.
Am J Gastroenterol. 1999 Apr;94(4):1077-82. doi: 10.1111/j.1572-0241.1999.929_b.x.
The somatostatin analogue, octreotide is valuable in the management of variceal bleeding, and it has been suggested that it may stop peptic ulcer hemorrhage by reducing gastroduodenal blood flow or increasing intragastric pH. The aim of this study was to determine the effect of intravenous octreotide infusion on gastroduodenal mucosal blood flow and gastric pH.
Seven New Zealand white rabbits and five healthy human volunteers were used. Mucosal blood flow was measured using a laser Doppler flowmeter (LDF). The Doppler probe was positioned in the upper gastrointestinal tract of the seven rabbits and five human volunteers. Blood flow was measured before and after octreotide infusion.
In the animal experiments, mucosal blood flow was decreased in a dose dependent manner in the gastric body (209.1-56.3 U) (p < 0.008), antrum (143.3-33.3 U) (p < 0.02) and duodenum (254-67.6 U) (p < 0.016) by doses of octreotide ranging from 10-50 microg/kg of body weight. In the human studies, mucosal blood flow was decreased in the gastric body (p < 0.016) and antrum (p < 0.009) after octreotide infusion (dose 1-1.5 microg/kg). Intragastric pH was significantly increased (p < 0.05). The change was not associated with systemic hemodynamic changes.
Gastroduodenal mucosal blood flow was reduced and intragastric pH increased by octreotide. This agent could be helpful in the management of gastroduodenal mucosal bleeding.
生长抑素类似物奥曲肽在静脉曲张出血的治疗中具有重要价值，有人认为它可能通过减少胃十二指肠血流或提高胃内pH值来止血。本研究旨在确定静脉输注奥曲肽对胃十二指肠黏膜血流和胃pH值的影响。
使用7只新西兰白兔和5名健康人类志愿者。采用激光多普勒血流仪（LDF）测量黏膜血流。将多普勒探头置于7只兔子和5名人类志愿者的上消化道。在输注奥曲肽前后测量血流。
在动物实验中，体重剂量为10 - 50微克/千克的奥曲肽使胃体（209.1 - 56.3 U）（p < 0.008）、胃窦（143.3 - 33.3 U）（p < 0.02）和十二指肠（254 - 67.6 U）（p < 0.016）的黏膜血流呈剂量依赖性降低。在人体研究中，输注奥曲肽（剂量1 - 1.5微克/千克）后，胃体（p < 0.016）和胃窦（p < 0.009）的黏膜血流降低。胃内pH值显著升高（p < 0.05）。这种变化与全身血流动力学变化无关。
奥曲肽可降低胃十二指肠黏膜血流并提高胃内pH值。该药物可能有助于治疗胃十二指肠黏膜出血。
