奥曲肽可降低正常胃和门脉高压胃的胃黏膜血流量。
Octreotide lowers gastric mucosal blood flow in normal and portal hypertensive stomachs.
作者信息
Clarke D L, McKune A, Thomson S R
机构信息
Department of General Surgery, Nelson R. Mandela School of Medicine, University of Natal, Private Bag 7, Congella, South Africa, 4013.
出版信息
Surg Endosc. 2003 Oct;17(10):1570-2. doi: 10.1007/s00464-002-9274-z. Epub 2003 Jul 21.
BACKGROUND
The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF.
METHODS
In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject.
RESULTS
After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension.
CONCLUSIONS
Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.
背景
血管活性肽奥曲肽在控制静脉曲张出血方面已确立其作用。其作用机制被认为是内脏血流量减少。内脏血流量的减少应反映为胃黏膜血流量（GMBF）的减少。激光多普勒血流仪（LDF）应能检测到GMBF的变化。
方法
对7名正常志愿者和4名门静脉高压患者静脉推注100μg奥曲肽。然后在胃窦中部的单个点进行连续LDF测量，持续至少10分钟，并针对每个受试者绘制随时间变化的曲线。
结果
经过一段不同的稳定期后，除1名受试者外，所有受试者的GMBF均下降。这在对照组和门静脉高压患者中均具有统计学意义。
结论
奥曲肽可降低正常和门静脉高压状态下胃的GMBF。激光多普勒是评估药物对GMBF影响的一种有用且微创的工具。
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