肿瘤发生的一般生物学方面。

General biological aspects of oncogenesis.

作者信息

D'Amato G, Patarca R

机构信息

Department of Internal Medicine, Jackson Memorial Hospital, Miami, FL, USA.

出版信息

Crit Rev Oncog. 1998;9(3-4):275-373.

PMID:10201632

Abstract

Both genetic and epigenetic events play an important role in oncogenic processes. This review discusses the four hypothesis for the origin of neoplastic transformation (mutational genetic, nonmutational genetic, viral, and epigenetic) in the context of a summary of our current knowledge of the pathobiology of cancer.

摘要

遗传事件和表观遗传事件在致癌过程中均起着重要作用。本综述在总结我们目前对癌症病理生物学认识的背景下，讨论了肿瘤转化起源的四种假说（突变遗传、非突变遗传、病毒和表观遗传）。