Nakagawa T, Yamane H, Shigeta T, Takashima T, Nakai Y
Department of Oto-Rhino-Laryngology, Yodogawa Christian Hospital, Osaka, Japan.
Laryngoscope. 1999 Apr;109(4):557-61. doi: 10.1097/00005537-199904000-00007.
The aim of this study was to determine roles of fibronectin and eosinophils in the etiology of nasal polyposis.
We designed a cohort study of cases with nasal polyposis. Sampled nasal polyps were differentiated by their histopathologic characteristics, and compared by size and computed tomography (CT) stage.
The size of nasal polyps was determined on the basis of the endoscopic findings, and the extent of sinusitis was evaluated by CT staging. Nasal polyp samples were taken from 82 patients during ethmoidectomy and differentiated by morphologic characteristics, infiltration cell types, or fibronectin positivity. Then their sizes and CT stages were compared. In addition, correlation among these histological characteristics was analyzed.
Nasal polyps showing edematous morphology, eosinophil infiltration, or fibronectin expression were significantly large in size. Concerning CT stages, only the infiltration cell type showed a significant difference. Significant correlation among edematous morphology, eosinophil infiltration, and fibronectin expression was also recognized.
These findings suggest that interaction between eosinophils and fibronectin may play a role in edema formation, which contributes to the growth of nasal polyps.
本研究旨在确定纤连蛋白和嗜酸性粒细胞在鼻息肉病病因学中的作用。
我们设计了一项针对鼻息肉病例的队列研究。对采集的鼻息肉根据其组织病理学特征进行区分，并按大小和计算机断层扫描（CT）分期进行比较。
根据内镜检查结果确定鼻息肉的大小，并通过CT分期评估鼻窦炎的程度。在筛窦切除术期间从82例患者中采集鼻息肉样本，并根据形态学特征、浸润细胞类型或纤连蛋白阳性进行区分。然后比较它们的大小和CT分期。此外，分析了这些组织学特征之间的相关性。
表现为水肿形态、嗜酸性粒细胞浸润或纤连蛋白表达的鼻息肉在大小上显著更大。关于CT分期，只有浸润细胞类型显示出显著差异。水肿形态、嗜酸性粒细胞浸润和纤连蛋白表达之间也存在显著相关性。
这些发现表明嗜酸性粒细胞与纤连蛋白之间的相互作用可能在水肿形成中起作用，这有助于鼻息肉的生长。
