Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate.
作者信息
Srivastava S, Tewari S, Chauhan P M, Puri S K, Bhaduri A P, Pandey V C
机构信息
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
出版信息
Bioorg Med Chem Lett. 1999 Mar 8;9(5):653-8. doi: 10.1016/s0960-894x(99)00058-x.
Abstract
Synthesis of a number of derivatives of bisquinolines (3-9) have been reported here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5 & 7), showing negligible methemoglobin toxicity.
摘要
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