双喹啉的合成及其在犬溶血产物中产生高铁血红蛋白的体外能力。
Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate.
作者信息
Srivastava S, Tewari S, Chauhan P M, Puri S K, Bhaduri A P, Pandey V C
机构信息
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
出版信息
Bioorg Med Chem Lett. 1999 Mar 8;9(5):653-8. doi: 10.1016/s0960-894x(99)00058-x.
Abstract
Synthesis of a number of derivatives of bisquinolines (3-9) have been reported here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5 & 7), showing negligible methemoglobin toxicity.
摘要
本文报道了多种双喹啉衍生物（3 - 9）的合成。这些化合物对体外高铁血红蛋白形成和高铁血红蛋白还原酶活性的影响，鉴定出了两种潜在化合物（5和7），其高铁血红蛋白毒性可忽略不计。
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