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Effects of 3alpha- and 3beta-galactosylated alpha-galactosylceramides on the immune system.

作者信息

Sakai T, Morita M, Matsunaga N, Akimoto K, Yokoyama T, Iijima H, Koezuka Y

机构信息

Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.

出版信息

Bioorg Med Chem Lett. 1999 Mar 8;9(5):697-702. doi: 10.1016/s0960-894x(99)00054-2.

DOI:10.1016/s0960-894x(99)00054-2
PMID:10201831
Abstract

We compared effects of alpha-galactosylceramide (alpha-GalCer) and its 3alpha- or 3beta-galactosylated derivatives on the proliferation of murine spleen cells. The 3alpha-galactosylated alpha-GalCer showed stronger proliferative response than the parental alpha-GalCer, but the 3beta-galactosylated alpha-GalCer possessed weaker activity than the alpha-GalCer. In addition, alpha-Gal-3-Cer did not show immunostimulatory activity.

摘要

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