Sakai T, Ueno H, Natori T, Uchimura A, Motoki K, Koezuka Y
Pharmaceutical Research Laboratory, Kirin Brewery Company, Ltd., Gunma, Japan.
J Med Chem. 1998 Feb 12;41(4):650-2. doi: 10.1021/jm970613v.
In contrast to the immunosuppressive effects of C2-ceramide (C2-Cer), alpha-galactosylceramides with ceramides having more than 10 carbons in fatty acid chains have immunostimulatory activities. We therefore synthesized alpha- and beta-galactosylated C2-Cers in order to examine their effects on the immune system. beta-Galactosylated C2-Cer and C2-Cer suppressed the allogeneic mixed leukocyte reaction (MLR) responses, but alpha-galactosylated C2-Cer stimulated the MLR response.
与C2-神经酰胺（C2-Cer）的免疫抑制作用相反，脂肪酸链中含有超过10个碳的神经酰胺的α-半乳糖神经酰胺具有免疫刺激活性。因此，我们合成了α-和β-半乳糖基化的C2-Cer，以研究它们对免疫系统的影响。β-半乳糖基化的C2-Cer和C2-Cer抑制了同种异体混合淋巴细胞反应（MLR），但α-半乳糖基化的C2-Cer刺激了MLR反应。
