Neufeld M Y, Kogan E, Chistik V, Korczyn A D
Department of Neurology, Tel-Aviv Sourasky Medical Center, Israel.
Clin Neuropharmacol. 1999 Mar-Apr;22(2):80-6. doi: 10.1097/00002826-199903000-00003.
Information on the effects of newer antiepileptic drug (AEDs) on the electroencephalogram (EEG) is sparse and contradictory. Quantitative EEG (qEEG) provides a method of estimating the effects of drugs on the central nervous system. Twenty-three adult patients with difficult-to-control complex partial seizures, with or without secondary generalization, participated in an add-on study with one of three newer AEDs: vigabatrin (n = 10), lamotrigine (n = 6), and topiramate (n = 7). Frequency analysis and topographic mapping of awake EEGs before and during treatment with the drug were compared. Statistical analysis was performed using 2-way analysis of variance (ANOVA) with repeated measures. Vigabatrin administration was followed by a diffuse decrease in the absolute alpha (p < 0.05) and beta (p < 0.02) activities and a decrease in the absolute theta in the frontal and parieto-occipital regions (p < 0.03). Lamotrigine caused a significant diffuse increase in the faster frequencies (relative alpha p < 0.04 and relative beta p < 0.02), and decrease in the slower activities (relative theta in the posterior head regions p < 0.03 and relative delta diffusely p < 0.05). Topiramate increased the absolute beta (p < 0.05) and theta (p < 0.02) activities diffusely and decreased the relative alpha activity over the left hemisphere (p < 0.03). The different effect profiles of the newer AEDs on the electrical brain activity may reflect their different mechanisms of action.
关于新型抗癫痫药物（AEDs）对脑电图（EEG）影响的信息稀少且相互矛盾。定量脑电图（qEEG）提供了一种评估药物对中枢神经系统影响的方法。23例患有难以控制的复杂部分性发作、伴或不伴继发性全身性发作的成年患者参与了一项附加研究，使用三种新型AEDs之一进行治疗：氨己烯酸（n = 10）、拉莫三嗪（n = 6）和托吡酯（n = 7）。比较了用药前和用药期间清醒EEG的频率分析和地形图。采用重复测量的双向方差分析（ANOVA）进行统计分析。服用氨己烯酸后，绝对α波（p < 0.05）和β波（p < 0.02）活动普遍降低，额叶和顶枕叶区域的绝对θ波降低（p < 0.03）。拉莫三嗪使较快频率显著普遍增加（相对α波p < 0.04，相对β波p < 0.02），较慢活动降低（后头部区域的相对θ波p < 0.03，相对δ波普遍p < 0.05）。托吡酯普遍增加绝对β波（p < 0.05）和θ波（p < 0.02）活动，并降低左半球的相对α波活动（p < 0.03）。新型AEDs对脑电活动的不同作用模式可能反映了它们不同的作用机制。
