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Cytometry. 1997 Dec 15;30(6):317-23.
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Cancer. 1998 Jan 1;82(1):86-95.
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Comparison between Ki-67 index and S-phase fraction on fine-needle aspiration samples from breast carcinoma.乳腺癌细针穿刺样本中Ki-67指数与S期细胞分数的比较。
Cancer. 1997 Oct 25;81(5):287-92.
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Cancer. 1997 May 1;79(9):1710-6.
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9
Differences in cell proliferation and prognostic significance of proliferating cell nuclear antigen and Ki-67 antigen immunoreactivity in in situ and invasive carcinomas of the extrahepatic biliary tract.肝外胆管原位癌和浸润癌中增殖细胞核抗原及Ki-67抗原免疫反应性的细胞增殖差异及其预后意义
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10
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MIB-1指数和DNA倍体在可切除的壶腹癌中的预后价值。

Prognostic value of MIB-1 index and DNA ploidy in resectable ampulla of Vater carcinoma.

作者信息

Shyr Y M, Su C H, Wu L H, Li A F, Chiu J H, Wu C W, Lui W Y

机构信息

Department of Surgery, Veterans General Hospital-Taipei, National Yang Ming University, Taiwan, Republic of China.

出版信息

Ann Surg. 1999 Apr;229(4):523-7. doi: 10.1097/00000658-199904000-00011.

DOI:10.1097/00000658-199904000-00011
PMID:10203085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1191738/
Abstract

OBJECTIVE

To evaluate the prognostic value of the proliferative factors, MIB-1 index, DNA ploidy, and S-phase fraction, and further to determine the independent prognostic factors in ampulla of Vater carcinoma after pancreaticoduodenectomy.

SUMMARY BACKGROUND DATA

Cell kinetics are important indicators of the biologic behavior of various human tumors, but only a few authors have reported the application of cell proliferative factors in ampulla of Vater carcinoma.

METHODS

Patients undergoing pancreaticoduodenectomy for ampulla of Vater carcinoma were included. Proliferative factors, MIB-1 index, and DNA contents, measured by flow cytometry, were evaluated and compared with the conventional clinicopathologic factors.

RESULTS

Ninety resectable ampulla of Vater carcinomas were included. By univariate analysis, MIB-1 index, DNA ploidy, S-phase fraction, stage, and lymph node status were significant prognostic factors. The 5-year survival rate was 40.7% for tumors with MIB-1 index < or =15% and 0% for those with MIB-1 index >15%. Diploid tumors had a significantly better prognosis than aneuploid. Outcomes of stage I and II tumors were more favorable than those of stage III and IV. After multivariate analysis, MIB-1 index, DNA ploidy, and stage remained as the independent prognostic factors. Among the three independent prognostic factors, MIB-1 index was the most powerful.

CONCLUSIONS

Both MIB-1 index and DNA ploidy provide important prognostic value and potentially complement the conventional prognostic factors in resectable ampulla of Vater carcinoma. MIB-1 index is the most powerful independent prognostic factor.

摘要

目的

评估增殖因子、MIB-1指数、DNA倍体及S期细胞分数的预后价值，并进一步确定胰十二指肠切除术后 Vater 壶腹癌的独立预后因素。

总结背景数据

细胞动力学是各种人类肿瘤生物学行为的重要指标，但仅有少数作者报道了细胞增殖因子在 Vater 壶腹癌中的应用。

方法

纳入因 Vater 壶腹癌接受胰十二指肠切除术的患者。评估通过流式细胞术测量的增殖因子、MIB-1指数及DNA含量，并与传统临床病理因素进行比较。

结果

纳入90例可切除的 Vater 壶腹癌。单因素分析显示，MIB-1指数、DNA倍体、S期细胞分数、分期及淋巴结状态是显著的预后因素。MIB-1指数≤15%的肿瘤5年生存率为40.7%，而MIB-1指数>15%的肿瘤5年生存率为0%。二倍体肿瘤的预后明显优于非整倍体肿瘤。I期和II期肿瘤的预后比III期和IV期更有利。多因素分析后，MIB-1指数、DNA倍体及分期仍是独立的预后因素。在这三个独立预后因素中，MIB-1指数的预后价值最强。

结论

MIB-1指数和DNA倍体均具有重要的预后价值，并可能补充可切除 Vater 壶腹癌的传统预后因素。MIB-1指数是最有力的独立预后因素。