Feucht H H, Schröter M, Zöllner B, Polywka S, Laufs R
Institute of Medical Microbiology and Immunology, Universitäts-Krankenhaus Eppendorf, Hamburg, Germany.
J Clin Microbiol. 1999 May;37(5):1294-7. doi: 10.1128/JCM.37.5.1294-1297.1999.
Until now there have been few seroepidemiological data for hepatitis G virus/GB virus type C (HGV/GBV-C). A four-antigen HGV/GBV-C immunoblot was established to examine 446 serum specimens from healthy individuals without risk factors for parenteral viral transmission. These individuals were divided into seven groups according to age. Seroprevalence rates were low for children and adolescents (5.6%) and increased for the age groups assumed to be the most sexually active (15.3 to 26.8%). Remarkably, none of the 80 individuals who tested positive for HGV/GBV-C antibodies were simultaneously positive for HGV/GBV-C viremia. From our data we conclude that HGV/GBV-C infection is widespread in the general population (16 to 25%). The development of an antibody response is associated with clearance of HGV/GBV-C viremia. Due to the lack of risk factors for HGV/GBV-C infection of blood, other efficient transmission routes must exist. It must be assumed that HGV/GBV-C transmission may be linked to sexual activity.
迄今为止，庚型肝炎病毒/GBV-C型肝炎病毒（HGV/GBV-C）的血清流行病学数据很少。建立了一种四抗原HGV/GBV-C免疫印迹法，用于检测446份来自无肠道外病毒传播危险因素的健康个体的血清标本。这些个体根据年龄分为七组。儿童和青少年的血清阳性率较低（5.6%），而在被认为性活动最为活跃的年龄组中血清阳性率有所上升（15.3%至26.8%）。值得注意的是，80例HGV/GBV-C抗体检测呈阳性的个体中，没有一例同时出现HGV/GBV-C病毒血症阳性。根据我们的数据，我们得出结论，HGV/GBV-C感染在普通人群中广泛存在（16%至25%）。抗体反应的产生与HGV/GBV-C病毒血症的清除有关。由于缺乏血液感染HGV/GBV-C的危险因素，必然存在其他有效的传播途径。必须假定HGV/GBV-C的传播可能与性活动有关。
