Gil A, González A, Dal-Ré R, Ortega P, Dominguez V
Preventive Medicine and Public Health Department, School of Medicine, Complutense University, Madrid, Spain.
J Infect. 1998 Jan;36(1):53-6. doi: 10.1016/s0163-4453(98)93126-7.
The aim of this cross-sectional study was to assess the seroprevalence of antibodies against varicella zoster (VZV), herpes simplex type 1 (HSV-1) and type 2 (HSV-2), hepatitis B (HBV) and hepatitis A (HAV) viruses in adolescents (14-17 years of age) in Madrid, Spain. At the study visit, demographic data and blood samples were obtained. The enzyme linked immunosorbent assay (ELISA) method was used to assess the presence of anti-VZV, anti-HSV-1, anti-HSV-2, anti-HBc and anti-HAV antibodies. A total of 1191 serum samples were collected. Mean age (SD) and male/female ratio of the study population were 15.3 (1.1) years and 0.9, respectively. Seroprevalences obtained were as follows: anti-VZV (94%), anti-HSV-1 (46%), anti-HSV-2 (5%), anti-HBc (3%) and anti-HAV (5%). These data show that Spanish adolescents should be considered a target group for prevention programmes against HSV-2, HBV and HAV infections.
这项横断面研究的目的是评估西班牙马德里14至17岁青少年中抗水痘带状疱疹病毒（VZV）、单纯疱疹病毒1型（HSV-1）和2型（HSV-2）、乙型肝炎病毒（HBV）和甲型肝炎病毒（HAV）抗体的血清流行率。在研究访视时，收集了人口统计学数据和血样。采用酶联免疫吸附测定（ELISA）方法评估抗VZV、抗HSV-1、抗HSV-2、抗HBc和抗HAV抗体的存在情况。共收集了1191份血清样本。研究人群的平均年龄（标准差）和男女比例分别为15.3（1.1）岁和0.9。获得的血清流行率如下：抗VZV（94%）、抗HSV-1（46%）、抗HSV-2（5%）、抗HBc（3%）和抗HAV（5%）。这些数据表明，西班牙青少年应被视为预防HSV-2、HBV和HAV感染的目标群体。
