Lishmanov Iu B, Maslov L N, Naumova A V, Bogomaz S A
Research Institute of Cardiology, Russian Acad. Med. Sci., Siberian Branch, Tomsk, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Nov;84(11):1223-30.
Stimulation of mu-opioid receptors was found to contribute to prevention of myocardial contractile dysfunction and ventricular arrhythmias in ischemia and reperfusion of the rat isolated heart. Endogenous agonists of the mu-opioid receptors were not involved in tonic regulation of the heart resistance against reperfusion disturbances of the rhythm and contractility. On the other hand, mu-opioid receptors are important for development of postischemic contracture.
研究发现，刺激μ-阿片受体有助于预防大鼠离体心脏缺血再灌注时的心肌收缩功能障碍和室性心律失常。μ-阿片受体的内源性激动剂不参与心脏抵抗再灌注时节律和收缩性紊乱的紧张性调节。另一方面，μ-阿片受体对缺血后挛缩的发展很重要。
