Maslov L N, Lasukova T V, Lishmanov Iu B
Research Institute of Cardiology of the Russian Acad. Med. Sci., Siberian Branch, Tomsk, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 May-Jun;84(5-6):490-9.
Under conditions of postischemic reperfusion, significance of endogenous opioid receptors' agonists for regulation of the myocardial contractility becomes enhanced. The sigma-receptor blocking contributes to a decrease in postischemic contracture and preservation of the cardiac cell membrane integrity. In sigma-receptor blockade, reoxygenation contracture does not appear. Preliminary mu-receptor blocking leads to an almost complete restitution of the heart contractility and decreases sarcolemma damage during postischemic period.
在缺血后再灌注条件下，内源性阿片受体激动剂对心肌收缩力调节的重要性增强。σ受体阻断有助于减少缺血后挛缩并维持心肌细胞膜完整性。在σ受体阻断时，再氧合挛缩不会出现。预先进行μ受体阻断可使心脏收缩力几乎完全恢复，并减少缺血后期间肌膜损伤。
