Kholod N S
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia.
Biochemistry (Mosc). 1999 Mar;64(3):298-306.
Available data on formation of dimers and other oligomers by "mature" tRNAs and the transcripts of their genes show that the dimers may be formed in vitro during the purification of individual tRNAs as well as on heating and subsequent cooling of tRNA preparations. The functional activity of dimers varies for different tRNAs. Structural analysis of tRNAs that are able or unable to form dimers suggests the importance of the hairpin melting temperature for dimer formation. Pathways of dimer formation and specific structural features of tRNA dimers are discussed.
关于“成熟”tRNA及其基因转录本形成二聚体和其他寡聚体的现有数据表明，二聚体可能在体外单个tRNA纯化过程中形成，也可能在tRNA制剂加热及随后冷却时形成。不同tRNA的二聚体功能活性各不相同。对能够或不能形成二聚体的tRNA进行结构分析，表明发夹解链温度对二聚体形成很重要。本文讨论了二聚体的形成途径及tRNA二聚体的特定结构特征。
