Kruysse A, Feron V J
Zentralbl Bakteriol Orig B. 1976 Dec;163(5-6):448-57.
Effects of cyclopentenone inhalation were examined in a 78-week study with 420 hamsters evenly distributed over two inhalation chambers, one for exposure to air and the other for exposure to the test substance. Cyclopentenone was dosed at a level of 18 ppm (seven hr/day, five days/week) during the first 52 weeks, and at a level of 27 ppm during the last 26 weeks of the study. During the first 52 weeks, part of the animals in both chambers fortnightly received an intratracheal instillation of benzo(a)pyrene (BP) or diethylnitrosamine (DENA) in saline or saline alone. Exposure to cyclopentenone caused slight growth depression in both sexes, and slightly increased relative liver weights and enhanced development of renal amyloidosis in females only. There was no evidence of cyclopentenonne possessing carcinogenic activity or being a co-factor in respiratory tract carcinogenesis.
在一项为期78周的研究中，对420只仓鼠吸入环戊烯酮的影响进行了检测，这些仓鼠被均匀分布在两个吸入舱中，一个用于暴露于空气中，另一个用于暴露于受试物质中。在研究的前52周，环戊烯酮的给药水平为18 ppm（每天7小时，每周5天），在研究的最后26周，给药水平为27 ppm。在前52周期间，两个舱室中的部分动物每两周接受一次气管内滴注苯并(a)芘（BP）或二乙基亚硝胺（DENA）的生理盐水溶液或仅生理盐水。暴露于环戊烯酮会导致两性动物的生长略有抑制，仅雌性动物的相对肝脏重量略有增加，肾淀粉样变性的发展增强。没有证据表明环戊烯酮具有致癌活性或作为呼吸道致癌作用的辅助因素。
