Zakrzewska-Pniewska B, Gasik R, Kostera-Pruszczyk A, Emeryk-Szajewska B
Department of Neurology, Warsaw Medical School, Poland.
Electromyogr Clin Neurophysiol. 1999 Mar;39(2):107-12.
The frequency of involvement of sensory pathways in motor neuron disease (MND) remains the matter of controversy. For this reason the purpose of the present work was to test how often sensory system involvement might be detected by somatosensory evoked potentials (SEP) studies and then to verify the presence of alteration of the sensory conduction and to detect the frequency of abnormalities of somatosensory peripheral, spinal, subcortical and cortical potentials in MND. SEP were tested after median nerve stimulation at the wrist, recorded from Erb's point, Ce2, Ce7 and scalp. Pearson's correlation coefficients test and Wilcoxon rank-sum test were used for statistical analysis. 74 patients (22 women and 52 men) were examined. Mean age of patients was 54.07 +/- 11.24 years; mean duration of the disease -19.25 +/- 15.87 months. SEP were abnormal in 39 of 74 patients (about 53%) whereas the sensory NCV in median nerve was abnormal in 14 of 74 patients (19%). The most frequent pattern of abnormalities consisted of the absence or delay of cortical responses. The mean values of SEP latencies (N9, N11, N13, N20 and P25) were significantly increased in MND patients (p < 0.05) as compared with controls. The N9 and N11 latencies correlated with the duration of the disease. The results of our study (concerning a large group of MND patients) suggest that the involvement of sensory pathways is not rare in MND.
感觉通路在运动神经元病（MND）中的受累频率仍存在争议。因此，本研究的目的是检测体感诱发电位（SEP）研究能多频繁地检测到感觉系统受累，然后验证感觉传导是否存在改变，并检测MND中体感外周、脊髓、皮质下和皮质电位异常的频率。在腕部正中神经刺激后检测SEP，记录部位为Erb点、C2、C7和头皮。采用Pearson相关系数检验和Wilcoxon秩和检验进行统计分析。共检查了74例患者（22例女性和52例男性）。患者的平均年龄为54.07±11.24岁；疾病的平均病程为19.25±15.87个月。74例患者中有39例（约53%）SEP异常，而74例患者中有14例（19%）正中神经感觉神经传导速度（NCV）异常。最常见的异常模式包括皮质反应缺失或延迟。与对照组相比，MND患者SEP潜伏期（N9、N11、N13、N20和P25）的平均值显著增加（p<0.05）。N9和N11潜伏期与疾病持续时间相关。我们的研究结果（涉及一大组MND患者）表明，感觉通路受累在MND中并不罕见。
