转录调控：开关电路。

Transcriptional regulation: SWItching circuitry.

作者信息

Wade P A, Wolffe A P

机构信息

Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892-5431, USA.

出版信息

Curr Biol. 1999 Mar 25;9(6):R221-4. doi: 10.1016/s0960-9822(99)80134-1.

DOI:10.1016/s0960-9822(99)80134-1

PMID:10209086

Abstract

Proteins of the SWI/SNF family disrupt chromatin, hydrolysing ATP in the process. How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription.

摘要

SWI/SNF家族的蛋白质会破坏染色质，并在此过程中水解ATP。它们如何做到这一点仍然是个谜，但最近的研究表明，它们可以靶向核基础设施和特定基因，在那里它们与其他酶协同作用以激活或抑制转录。