G蛋白偶联受体对酪氨酸激酶级联反应的调控

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

作者信息

Luttrell L M, Daaka Y, Lefkowitz R J

机构信息

The Howard Hughes Medical Institute, Departments of Medicine, Surgery and Biochemistry, Box 3821, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Curr Opin Cell Biol. 1999 Apr;11(2):177-83. doi: 10.1016/s0955-0674(99)80023-4.

DOI:10.1016/s0955-0674(99)80023-4

PMID:10209148

Abstract

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes. Over the past three years, three types of scaffolds for GPCR-directed complex assembly have been identified: transactivated receptor tyrosine kinases (RTKs), integrin-based focal adhesions, and GPCRs themselves. Nonreceptor tyrosine kinases play an important role in each case. The processes of GPCR desensitization and sequestration via clathrin-coated pits are also involved in signaling through the RTK- and GPCR-based scaffolds.

摘要

G蛋白偶联受体（GPCRs）介导的促有丝分裂信号传导涉及衔接蛋白的酪氨酸磷酸化以及多蛋白Ras激活复合物的组装。在过去三年中，已鉴定出三种用于GPCR导向复合物组装的支架：反式激活的受体酪氨酸激酶（RTKs）、基于整合素的粘着斑以及GPCR自身。在每种情况下，非受体酪氨酸激酶都发挥着重要作用。通过网格蛋白包被小窝进行的GPCR脱敏和隔离过程也参与基于RTK和GPCR的支架信号传导。