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Converging evidence for functional connections between the lithium response and PI3K-Akt signaling.

作者信息

Dwyer Donard S

机构信息

Departments of Psychiatry and Behavioral Medicine, and Pharmacology, Toxicology and Neuroscience, LSU Health Shreveport, Shreveport, LA, USA.

出版信息

Transl Psychiatry. 2024 Nov 1;14(1):458. doi: 10.1038/s41398-024-03160-y.

DOI:10.1038/s41398-024-03160-y
PMID:39487122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11530542/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03a9/11530542/dd83b07b805b/41398_2024_3160_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03a9/11530542/dd83b07b805b/41398_2024_3160_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03a9/11530542/dd83b07b805b/41398_2024_3160_Fig1_HTML.jpg

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Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants.可产生动机减退并可被氯氮平、锂盐及抗抑郁药纠正的假定自杀相关风险基因的进化保守性。
Front Psychiatry. 2024 Feb 1;15:1341735. doi: 10.3389/fpsyt.2024.1341735. eCollection 2024.
3
Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension.
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Clin Sci (Lond). 2022 Jun 17;136(11):803-817. doi: 10.1042/CS20220226.
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Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected.双相情感障碍的候选风险基因在进化过程中高度保守且高度相互关联。
Bipolar Disord. 2021 Jun;23(4):400-408. doi: 10.1111/bdi.12996. Epub 2020 Oct 13.
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Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability.令人惊讶的是，较低等生物中精神分裂症风险基因的保守性反映了它们的基本功能和遗传易感性的进化。
Schizophr Res. 2018 Dec;202:120-128. doi: 10.1016/j.schres.2018.07.017. Epub 2018 Jul 13.
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The Emerging Neurobiology of Bipolar Disorder.双相障碍的新兴神经生物学。
Trends Neurosci. 2018 Jan;41(1):18-30. doi: 10.1016/j.tins.2017.10.006. Epub 2017 Nov 20.
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