Hood J K, Silver P A
Harvard Medical School and Dana-Farber Cancer Institute, Smith 922, 44 Binney Street, Boston, MA 02115, USA.
Curr Opin Cell Biol. 1999 Apr;11(2):241-7. doi: 10.1016/s0955-0674(99)80032-5.
The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, substrate phosphorylation has emerged as a common mechanism for controlling this interaction.
真核细胞的细胞核或细胞质内蛋白质的区室化作用为细胞周期进程和信号通路的调控提供了机会。蛋白质的核定位由其与特定核输入和输出因子相互作用的能力决定。在过去的一年里，底物磷酸化已成为控制这种相互作用的一种常见机制。
