Ashkenazi A, Dixit V M
Department of Molecular Oncology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Curr Opin Cell Biol. 1999 Apr;11(2):255-60. doi: 10.1016/s0955-0674(99)80034-9.
The death receptors Fas and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis upon engagement by their cognate death ligands. Recently, researchers have discovered several novel homologues of Fas and TNFR1: DR 3, 4, 5, and 6 function as death receptors that signal apoptosis, whereas DcR 1, 2, and 3 act as decoys that compete with specific death receptors for ligand binding. Further, mouse gene knockout studies have enabled researchers to delineate some of the signaling pathways that connect death receptors to the cell's apoptotic machinery.
死亡受体Fas和肿瘤坏死因子受体1（TNFR1）在与它们相应的死亡配体结合后会触发细胞凋亡。最近，研究人员发现了Fas和TNFR1的几种新的同源物：DR 3、4、5和6作为死亡受体发挥作用，发出细胞凋亡信号，而DcR 1、2和3则作为诱饵，与特定的死亡受体竞争配体结合。此外，小鼠基因敲除研究使研究人员能够描绘出一些将死亡受体与细胞凋亡机制联系起来的信号通路。
