Deretic V, Fratti R A
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.
Mol Microbiol. 1999 Mar;31(6):1603-9. doi: 10.1046/j.1365-2958.1999.01279.x.
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.
结核分枝杆菌吞噬体在受感染巨噬细胞中的成熟停滞，这一现象对于结核病发病机制而言具有双重意义，同时也是研究微生物干扰宿主细胞内膜运输和细胞器生物发生的模型系统。在诸多因素中，囊泡运输的区室特异性调节因子以及膜融合机制的其他部分，很可能在这些过程中发挥作用。在此，我们在细胞内膜运输动态过程的背景下，总结了关于分枝杆菌吞噬体成熟停滞的新观点。
