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本文引用的文献

1
Exercise before puberty may confer residual benefits in bone density in adulthood: studies in active prepubertal and retired female gymnasts.青春期前运动可能会为成年后的骨密度带来残留益处：对青春期前活跃及退役的女性体操运动员的研究。
J Bone Miner Res. 1998 Mar;13(3):500-7. doi: 10.1359/jbmr.1998.13.3.500.
2
Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms?膳食钙和年龄能否解释围绕骨密度与维生素D受体基因多态性之间关系的争议？
J Bone Miner Res. 1998 Mar;13(3):363-70. doi: 10.1359/jbmr.1998.13.3.363.
3
Genetic determination of bone density.
Lancet. 1997 Nov 1;350(9087):1263-4. doi: 10.1016/S0140-6736(05)62468-3.
4
Association between vitamin D receptor gene polymorphism and sex-dependent growth during the first two years of life.
J Clin Endocrinol Metab. 1997 Sep;82(9):2966-70. doi: 10.1210/jcem.82.9.4232.
5
Vitamin D-receptor gene polymorphisms and bone density in prepubertal American girls of Mexican descent.墨西哥裔美国青春期前女孩的维生素D受体基因多态性与骨密度
N Engl J Med. 1997 Jul 10;337(2):77-82. doi: 10.1056/NEJM199707103370202.
6
The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women.绝经前美国黑人和白人女性中维生素D受体起始密码子多态性（FokI）与骨密度的关系
J Bone Miner Res. 1997 Jul;12(7):1043-8. doi: 10.1359/jbmr.1997.12.7.1043.
7
Differential effect of gender on the sizes of the bones in the axial and appendicular skeletons.性别对中轴骨骼和附肢骨骼大小的差异影响。
J Clin Endocrinol Metab. 1997 May;82(5):1603-7. doi: 10.1210/jcem.82.5.3942.
8
Genetic markers of bone metabolism and bone disease.骨代谢与骨疾病的遗传标志物。
Scand J Clin Lab Invest Suppl. 1997;227:114-21.
9
Effect of 1,25(OH)2 vitamin D3 on circulating insulin-like growth factor-I and beta 2 microglobulin in patients with osteoporosis.1,25-二羟维生素D3对骨质疏松症患者循环胰岛素样生长因子-I及β2微球蛋白的影响
Calcif Tissue Int. 1997 Mar;60(3):236-9. doi: 10.1007/s002239900221.
10
Polymorphisms of the vitamin D receptor, infant growth, and adult bone mass.
Calcif Tissue Int. 1997 Mar;60(3):233-5. doi: 10.1007/s002239900220.

维生素D受体等位基因可预测女孩的生长和骨密度。

Vitamin D receptor alleles predict growth and bone density in girls.

作者信息

Tao C, Yu T, Garnett S, Briody J, Knight J, Woodhead H, Cowell C T

机构信息

Robert Vines Growth Research Centre, New Children's Hospital, Parramatta, NSW, Australia.

出版信息

Arch Dis Child. 1998 Dec;79(6):488-93; discussion 493-4. doi: 10.1136/adc.79.6.488.

DOI:10.1136/adc.79.6.488
PMID:10210992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1717763/
Abstract

OBJECTIVES

Polymorphism of the vitamin D receptor (VDR), collagen alpha I type I (Col I alpha I), and oestrogen receptor (ER) genes have been shown to account for some of the heritability of bone mineral density (BMD) in adults. This study examined this relation in prepubertal children.

METHODS AND SUBJECTS

The relation between genotypes of VDR gene (Taq I, Bsm I, Fok I), Col I alpha I gene (Msc I), and ER gene (Pvu II) with areal BMD, volumetric BMD, and growth were examined in 114 (68 girls) healthy 7 year old, white children.

RESULTS

The genotype of the VDR gene (Taq I) correlated with lumbar spine (L1-4) volumetric BMD in girls only, but at no other bone sites. In girls, VDR genotype affected areal BMD at all sites. After adjusting for height and weight, however, this effect was explained completely by the independent effect of the VDR genotype on growth. Girls with genotype TT, were 3.9 kg heavier and 4.1 cm taller than those with tt, but this relation was not present at birth. No relation was found between genotypes of the VDR gene (Fok I), Col I alpha I gene (Msc I), or ER gene (Pvu II) and BMD or growth variables.

CONCLUSIONS

In prepubertal girls, VDR alleles contribute to lumbar spine volumetric BMD variance, but the areal BMD effect reflects the relation between areal BMD and growth. VDR alleles might affect postnatal growth regulation.

摘要

目的

维生素D受体（VDR）、I型胶原蛋白α1（Col Iα1）和雌激素受体（ER）基因的多态性已被证明可解释成年人骨密度（BMD）的部分遗传力。本研究在青春期前儿童中检验了这种关系。

方法和研究对象

在114名（68名女孩）7岁健康白人儿童中，研究了VDR基因（Taq I、Bsm I、Fok I）、Col Iα1基因（Msc I）和ER基因（Pvu II）的基因型与面积骨密度、体积骨密度及生长之间的关系。

结果

仅在女孩中，VDR基因（Taq I）的基因型与腰椎（L1 - 4）体积骨密度相关，在其他骨部位则无此关联。在女孩中，VDR基因型影响所有部位的面积骨密度。然而，在调整身高和体重后，这种影响完全由VDR基因型对生长的独立作用所解释。基因型为TT的女孩比tt基因型的女孩重3.9千克，高4.1厘米，但这种关系在出生时不存在。未发现VDR基因（Fok I）、Col Iα1基因（Msc I）或ER基因（Pvu II）的基因型与骨密度或生长变量之间存在关联。

结论

在青春期前女孩中，VDR等位基因对腰椎体积骨密度变异有贡献，但面积骨密度效应反映了面积骨密度与生长之间的关系。VDR等位基因可能影响出生后的生长调节。