Jain R K, Piskorz C F, Chandrasekaran E V, Matta K L
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Glycoconj J. 1998 Oct;15(10):951-9. doi: 10.1023/a:1006977607394.
Our recent studies have revealed the existence of two distinct Gal: 3-O-sulfotransferases capable of acting on the C-3 position of galactose in a Core 2 branched structure, e.g., Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNacalph a1-->OBenzyl as acceptor to give 3-O-sulfoGalbeta1-->4GlcNAcbeta1-->3(Galbeta1-->3)G alNAcalpha1-->OB 20 and Galbeta1-->4GlcNAcbeta1-->6(3-O-sulfoGalbeta1-->3)G alNAcalpha1-->OB 23. We herein report the synthesis of these two compounds and also that of other modified analogs that are highly specific acceptors for the two sulfotransferases. Appropriately protected 1-thio-glycosides 7, 8, and 10 were employed as glycosyl donors for the synthesis of our target compounds.
我们最近的研究揭示了两种不同的半乳糖3 - O -磺基转移酶的存在，它们能够作用于核心2分支结构中半乳糖的C - 3位，例如，以Galβ1→4GlcNAcβ1→6(Galβ1→3)GalNAcalpha1→OBenzyl作为受体，生成3 - O - 磺基Galβ1→4GlcNAcβ1→3(Galβ1→3)GalNAcalpha1→OB 20和Galβ1→4GlcNAcβ1→6(3 - O - 磺基Galβ1→3)GalNAcalpha1→OB 23。我们在此报告这两种化合物以及其他修饰类似物的合成，这些类似物是这两种磺基转移酶的高度特异性受体。合适保护的1 - 硫代糖苷7、8和10被用作糖基供体来合成我们的目标化合物。
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